Journal of Cancer Research and Clinical Oncology

, Volume 131, Issue 1, pp 14–18

Expression of e-cadherin in high-risk breast cancer

  • Eugene M. Howard
  • Stephen K. Lau
  • Robert H. Lyles
  • George G. Birdsong
  • Jay N. Umbreit
  • Ruby Kochhar
Original Paper

Abstract

Purpose

E-cadherin expression is diverse, and differences in patient characteristics may produce variability in expression. Whereas some studies have indicated that downregulation of e-cadherin, associated with loss of cellular adhesiveness, was correlative with poor prognosis and metastasis, other studies have failed to confirm this. The present study uses a highly homogenous population of patients at high-risk for breast cancer, on the basis of ethnic and socio-economic status, to examine the relationship between e-cadherin and other prognostic markers in breast cancer.

Methods

Immunohistochemical staining was undertaken for estrogen (ER) and progesterone (PR) receptors, epidermal growth factor receptor 2 (Her-2), p53, vascular endothelial factor (VEGF), and hypoxia inducible factor 1α (HIF-1α) and the levels of these markers was compared to e-cadherin expression in a high-risk African-American patient population.

Results

E-cadherin expression persisted into the later stagers of the disease, and was strongly associated with Her-2 and HIF-1α expression, but not p53, ER/PR or VEGF.

Conclusions

In contrast to other studies on heterogeneous populations, e-cadherin is preserved in aggressive tumors in this high-risk population. The ethnic and socio-economic risk stratification needs to be accounted for in studies correlating markers and prognosis.

Keywords

Aggressive breast carcinoma E-cadherin HER-2 p53 VEGF HIF-1α Immunohistochemistry 

Abbreviations

HER-2

Human epidermal growth receptor 2

VEGF

Vascular endothelial growth factor

DCIS

Ductal carcinoma in situ

HIF-1α

Hypoxia inducible factor 1α

DFS

Disease-free survival

OS

Overall survival

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Eugene M. Howard
    • 1
  • Stephen K. Lau
    • 2
  • Robert H. Lyles
    • 3
  • George G. Birdsong
    • 2
  • Jay N. Umbreit
    • 1
  • Ruby Kochhar
    • 1
  1. 1.Winship Cancer InstituteEmory UniversityAtlantaUSA
  2. 2.Dept. of PathologyEmory University School of MedicineAtlantaUSA
  3. 3.Rollins School of Public Health at Emory UniversityAtlantaUSA

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