Journal of Cancer Research and Clinical Oncology

, Volume 130, Issue 11, pp 664–670 | Cite as

The impact of comorbidity on the survival of postmenopausal women with breast cancer

  • G. Nagel
  • U. Wedding
  • H. Hoyer
  • B. Röhrig
  • D. Katenkamp
Original Paper



The aim was to assess the impact of comorbidity on survival of postmenopausal women with breast cancer diagnosis in the period 1995–1997.


The level of comorbidity was described by the methods suggested by Satariano and Charlson. Cox’s proportional hazard models were used to explore the impact of comorbidity on all-cause mortality.


After a median follow-up time of 52 months, an increasing level of comorbidity was associated with a higher all-cause mortality. Compared to patients without comorbid conditions, the hazard ratio of death (HR) was 1.2 (95% CI: 0.8–1.7) for Satariano index 1 and HR 2.3 (95% CI: 1.5–3.5) for Satariano index ≥2, and HR 1.6 and 2.1 for the Charlson comorbidity index, respectively. Independent of comorbidity, the treatment pattern had a strong impact on survival. The level of comorbidity has an influence on the 3-year survival of postmenopausal women with breast cancer.


Long-term follow-up is required to appraise these findings in relation to treatment strategies.


Breast cancer Comorbidity Survival 



This study was supported by grants from the German Ministry of Health (FB2–43332–70/1). We are grateful to our documentation team and give thanks to S. Berg, I. Köhler, B. Osten and K. Polte.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • G. Nagel
    • 1
    • 4
  • U. Wedding
    • 2
  • H. Hoyer
    • 3
  • B. Röhrig
    • 3
  • D. Katenkamp
    • 1
  1. 1.Comprehensive Cancer Center/Field study Breast CancerFriedrich-Schiller-UniversityJenaGermany
  2. 2.Clinic Internal Medicine II, Hematology, Oncology, Gastroenterology, Hepatology and Infectious DiseaseFriedrich-Schiller-UniversityJenaGermany
  3. 3.Institute for Medical StatisticsComputer Sciences and DocumentationJenaGermany
  4. 4.Division of Clinical EpidemiologyDeutsches KrebsforschungszentrumHeidelbergGermany

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