European Journal of Pediatrics

, Volume 158, Issue 9, pp 698–701

Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

  • F. Aspesberro
  • M. Beghetti
  • I. Oberhänsli
  • H. Özsahin
  • J. Humbert
  • P. C. Rimensberger
CARDIOLOGY

Abstract

We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects.

Conclusion This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.

Key words Thrombolysis therapeutic Plasminogen activators Urokinase Thrombosis Infant Premature 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • F. Aspesberro
    • 1
  • M. Beghetti
    • 1
  • I. Oberhänsli
    • 1
  • H. Özsahin
    • 1
  • J. Humbert
    • 1
  • P. C. Rimensberger
    • 1
  1. 1.Critical Care, Cardiology and Hematology-Oncology, Department of Pediatrics, Hôspital des Enfants, University Hospital of Geneva, Rue Willy Donzé 6, CH-1211 Geneva 14, Switzerland, e-mail: Peter.Rimensberger@hcuge.ch, Tel.: 022/382 46 23, Fax: 022/382 46 75CH

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