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European Journal of Pediatrics

, Volume 158, Issue 8, pp 611–617 | Cite as

Analysing the developing lymphocyte system of neonates and infants

  • E. de Vries
  • R. de Groot
  • S. de Bruin-Versteeg
  • W. M. Comans-Bitter
  • J. J. M. van Dongen
REVIEW

Abstract

Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children.

Conclusion In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.

Key words Flow cytometry Immunophenotyping Infant Lymphocyte subsets Neonate 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • E. de Vries
    • 2
  • R. de Groot
    • 1
  • S. de Bruin-Versteeg
    • 2
  • W. M. Comans-Bitter
    • 2
  • J. J. M. van Dongen
    • 2
  1. 1.Department of Paediatrics, University Hospital/Sophia Children's Hospital, Rotterdam, The Netherlands.NL
  2. 2.Department of Immunology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands, Tel.: +31-10-4088094 Fax: +31-10-4089456NL

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