European Journal of Pediatrics

, Volume 158, Issue 6, pp 484–487

A patent ductus arteriosus is associated with reduced middle cerebral artery blood flow velocity

  • F. J. Weir
  • A. Ohlsson
  • T. L. Myhr
  • K. Fong
  • M. L. Ryan
NEONATOLOGY

Abstract

The study objective was to determine the effect of a patent ductus arteriosus (PDA) on cerebral blood flow velocity in ventilated, very low birth weight neonates, in the first 5 days of life. Sonography of the right middle cerebral artery and ductus arteriosus was performed using a colour Doppler technique. Statistical analysis was by stepwise regression. Thirty-one neonates without and 43 with a PDA, mean (SD) birth weight 1004 g ± 192 and 1071 g ± 227 respectively, were studied. The end diastolic and mean velocities were reduced (P = 0.008 and P = 0.129) and the resistive index was increased (P = 0.047) by a PDA. pH was inversely related to end diastolic and mean velocities (P = 0.015 and P = 0.003), suggesting that low pH may increase cerebral artery blood flow velocity.

Conclusion A patent ductus arteriosus reduces middle cerebral artery blood flow velocity in very low birth weight neonates.

Key words Cerebral blood flow velocity Ductus arteriosus Infant-newborn Very low birth weight infant Colour Doppler 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • F. J. Weir
    • 2
  • A. Ohlsson
    • 2
  • T. L. Myhr
  • K. Fong
    • 1
  • M. L. Ryan
    • 2
  1. 1.Department of Medical Imaging, Women's College Hospital, Toronto, Ontario, CanadaCA
  2. 2.Department of Newborn and Developmental Paediatrics, Women's College Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada, e-mail address: aohlsson@globalserve.net, Tel.: +1-416-323-6268, Fax: +1-416-323-6274CA

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