Advertisement

European Journal of Pediatrics

, Volume 157, Issue 6, pp 475–478 | Cite as

Cardiac tamponade due to systemic lupus erythematosus in a 7-year-old boy with selective IgG subclass deficiency

  • A. Tamura
  • K. Agematsu
  • R. Urasawa
  • K. Naganuma
  • A. Komiyama
IMMUNOLOGY/ALLERGOLOGY

Abstract

Systemic lupus erythematosus (SLE) was observed in a 7-year-old boy with IgG2 and IgG4 subclass deficiencies who had been treated with immunoglobulin (100–200 mg/kg/4 weeks) since 2 years of age. The mother and the half-brother displayed the same deficiency. Serum IgG mainly consisted of IgG1 (98.9%) during the acute phase of SLE due to transient IgG3 deficiency. While he had no common manifestations of SLE such as arthritis or nephropathy, he developed cardiac tamponade due to massive pericardial effusion.

Conclusion The clinical features of SLE in the present case such as the development of cardiac tamponade and the absence of renal involvement may result from the markedly imbalanced IgG subclass distribution among auto-antibodies.

Key words Systemic lupus erythematosus Cardiac tamponade IgG subclass deficiency Auto-antibodies 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • A. Tamura
    • 1
  • K. Agematsu
    • 1
  • R. Urasawa
    • 1
  • K. Naganuma
    • 2
  • A. Komiyama
    • 1
  1. 1.Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, JapanJP
  2. 2.Department of Pediatrics, Iida Municipal hospital, Iida, JapanJP

Personalised recommendations