Advertisement

European Journal of Pediatrics

, Volume 156, Issue 6, pp 465–470 | Cite as

Blood transfusion

Iron load and retinopathy of prematurity
  • L. Hesse
  • W. Eberl
  • M. Schlaud
  • C. F. Poets
NEONATOLOGY

Abstract

To study the relationship between blood transfusion, iron load and retinopathy of prematurity (ROP), we performed a prospective observational cohort study in a level III neonatal intensive care unit. During a 24-month period, data on the volume of blood transfused during the first 6 weeks of life and on the incidence of ROP were collected in all surviving very low birth weight infants (n = 114 median birth weight␣1130␣g, range 520–1500 g). Associations between these data and values for serum iron, transferrin and ferritin measured at weekly intervals were analysed in a nested case-control design by logistic regression. There was a significant association between the volume of blood transfused and the incidence of ROP. After adjustment for gestational age at birth, duration of oxygen therapy FiO2> 0.3) and duration of mechanical ventilation, the relative risk of developing ROP was 6.4 (95% CI 1.2–33.4) for infants who had received 16–45 ml/kg, and 12.3 (1.6–92.5) for those who had received more than 45 ml/kg of blood (reference, 0–15 ml/kg). In contrast, there was no independent relationship between ROP and any of the parameters on iron metabolism analysed.

Conclusion This study confirms the role of blood transfusions as an independent risk factor for ROP. This relationship, however, does not appear to be mediated via an increased iron load.

Key words Retinopathy of prematurity   Iron overload   Oxygen radicals   Transfusion 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • L. Hesse
    • 1
  • W. Eberl
    • 2
  • M. Schlaud
    • 3
  • C. F. Poets
    • 4
  1. 1.Department of Ophthalmology, Philipps-University, Marburg, GermanyDE
  2. 2.Department of Paediatrics, City Hospital, Braunschweig, GermanyDE
  3. 3.Department of Epidemiology and Social Medicine, Medizinische Hochschule, Hannover, GermanyDE
  4. 4.Department of Paediatrics, Medizinische Hochschule, D-30623 Hannover, Germany Tel.: +49 511 532 9124; Fax: +49 511 532 9125DE

Personalised recommendations