Delayed diagnosis of congenital hypopituitarism associated with low socio-economic status and/or migration
The clinical presentation of combined pituitary hormone deficiency (CPHD) is variable. Some patients present with hypoglycemia during the neonatal period or during the first few years of life. Others present later in childhood with growth failure. We report on 7 patients with very late diagnosed severe hypopituitarism with pituitary stalk interruption syndrome. Five out of the 7 patients had recently migrated to Belgium and the 2 other patients were from low socio-economic status families. All of them presented to our clinic for short stature and some also complained of lack of pubertal development. Four out of the 7 patients reached final height which was within their target height, despite very delayed treatment.
What is Known:
• The clinical presentation of combined pituitary hormone deficiency (CPHD) is variable. Some patients present with hypoglycemia during the neonatal period or during the first few years of life. Others present later in childhood with growth failure.
• A few case reports are published with very late diagnosis of congenital hypopituitarism.
What is New:
• We report on the largest series of delayed diagnosis of congenital hypopituitarism and illustrate the survival of these children with overall good prognosis.
• Migration and social deprivation are thought to be the main cause of this late diagnosis.
KeywordsCongenital hypopituitarism Migration Delayed diagnosis Height Migrant children
EB, CB, and CH designed the study; EB and MC collected and analyzed the data. EB, MC, CB, and CH wrote the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article is a retrospective study, using already available data.
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