Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status
Vitamin D deficiency is common in Southeast Asia but there are limited data in pregnant women and neonates. This study aimed to determine the prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. A total of 94 pregnant women and their neonates were included. Clinical data and venous maternal blood for calcium, phosphate, albumin, alkaline phosphatase, magnesium, intact parathyroid hormone (iPTH), and vitamin D (25OHD) were obtained on the day of labor. Cord blood was collected following delivery to evaluate vitamin D status of newborns. Mean serum maternal and cord blood 25OHD levels were 25.42 ± 8.07 and 14.85 ± 5.13 ng/mL. The prevalence of vitamin D deficiency (25OHD < 12 ng/mL) and insufficiency (25OHD 12–20 ng/mL) in cord blood of newborns were 20.2 and 69.1%, respectively. There was a significant correlation between maternal and cord blood vitamin D levels (r = 0.86; P < 0.001). The factors associated with cord blood vitamin D deficiency were low maternal 25OHD level and no vitamin D supplement during pregnancy.
What is Known:
• Vitamin D deficiency is prevalent in Southeast Asia.
• There are widespread vitamin D deficiency among Thai populations including pregnant women.
What is New:
• There is a high prevalence of vitamin D deficiency among Thai neonates.
• The factors associated with cord blood vitamin D deficiency are low maternal vitamin D level and no vitamin D supplement during pregnancy.
KeywordsVitamin D deficiency Cord blood Newborns Pregnancy
Intact parathyroid hormone
Vitamin D deficiency
We would like to thank the patients and their families for participation in this study and Dr. Somchit Jaruratanasirikul for her constructive comments on our work and her editing of the text.
KA conceived of the study, participated in its design, analysis and interpretation of data, and drafted the manuscript. PL participated in the design of study, acquisition of data and coordination of the study. All authors read and approved the final manuscript.
This study was supported by the Panyananthaphikkhu Chonprathan Medical Center research funding.
Compliance with ethical standards
All procedures were performed according to the Declaration of Helsinki and approved by the Ethics Committee, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University. Informed consent was obtained from all individual participants included in the study.
Conflict of interest
The authors declare that they have no conflict of interest and do not have a financial relationship with the organization that sponsored the research.
The authors have nothing to disclose.
- 3.Charatcharoenwitthaya N, Nanthakomon T, Somprasit C, Chanthasenanont A, Chailurkit LO, Pattaraarchachai J, Ongphiphadhanakul B (2013) Maternal vitamin D status, its associated factors and the course of pregnancy in Thai women. Clin Endocrinol 78(1):126–133. https://doi.org/10.1111/j.1365-2265.2012.04470.x CrossRefGoogle Scholar
- 4.do Prado MR, Oliveira Fde C, Assis KF, Ribeiro SA, do Prado Junior PP, Sant’Ana LF, Priore SE, Franceschini Sdo C (2015) Prevalence of vitamin D deficiency and associated factors in women and newborns in the immediate postpartum period. Rev Paul Pediatr 33(3):287–294. https://doi.org/10.1016/j.rpped.2015.01.006 CrossRefPubMedGoogle Scholar
- 9.Manzano Varo C, Garcia-Algar O, Mur Sierra A, Ferrer Costa R, Carrascosa Lezcano A, Yeste Fernandez D, Ortigosa Gomez S (2017) Plasma 25-OH vitamin D concentrations in cord blood after summer months, Spain. Rev Esp Salud Publica 91Google Scholar
- 11.Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Makitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Savendahl L, Khadgawat R, Pludowski P, Maddock J, Hypponen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Hogler W (2016) Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab 101(2):394–415. https://doi.org/10.1210/jc.2015-2175 CrossRefPubMedPubMedCentralGoogle Scholar
- 13.Nimitphong H, Chailurkit LO, Chanprasertyothin S, Sritara P, Ongphiphadhanakul B (2013) The association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais. BMC Endocr Disord 13:60. https://doi.org/10.1186/1472-6823-13-60 CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Pratumvinit B, Wongkrajang P, Wataganara T, Hanyongyuth S, Nimmannit A, Chatsiricharoenkul S, Manonukul K, Reesukumal K (2015) Maternal vitamin D status and its related factors in pregnant women in Bangkok, Thailand. PLoS One 10(7):e0131126. https://doi.org/10.1371/journal.pone.0131126 CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Rojroongwasinkul N, Kijboonchoo K, Wimonpeerapattana W, Purttiponthanee S, Yamborisut U, Boonpraderm A, Kunapan P, Thasanasuwan W, Khouw I (2013) SEANUTS: the nutritional status and dietary intakes of 0.5-12-year-old Thai children. Br J Nutr 110(Suppl 3):S36–S44. https://doi.org/10.1017/S0007114513002110 CrossRefPubMedGoogle Scholar
- 18.Vinkhuyzen AA, Eyles DW, Burne TH, Blanken LM, Kruithof CJ, Verhulst F, Jaddoe VW, Tiemeier H, McGrath JJ (2015) Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: The Generation R Study. J Steroid Biochem Mol Biol 164:161–167. https://doi.org/10.1016/j.jsbmb.2015.09.018 CrossRefPubMedGoogle Scholar