Prediction of childhood obesity with or without vitamin D deficiency
KeywordsObesity Insulin Resistance Adipose Tissue Metabolic Syndrome Plasma Glucose
With interest, I have read the article by Manios et al. about CORE-index as a screening tool for the early identification of infants that are potentially at higher risk for becoming obese at their childhood and adolescence . I have the following comments.
Childhood obesity is an international public health problem leading to an increased risk of adult obesity and associated with mortality and morbidity . Vitamin D may regulate adipose tissue mass, differentiation, and metabolism in ways that might contribute to overweight and/or obesity possibly by effects on lipogenesis and/or adipogenesis . Vitamin D has been found to be a predictor significantly associated with overweight and/or obesity and other components of metabolic syndrome including raised plasma glucose concentration and insulin resistance . Ekbom et al.  reported that higher vitamin D levels were related to a decreased lipid profile in obese children and adolescents.
In this context, considering close association of vitamin D with both childhood obesity and metabolic syndrome parameters, in order to predict childhood obesity, new scoring system including CORE-index and serum vitamin D level might be beneficial.
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Conflict of interest
The author declares that he has no conflict of interest.
- 3.Manios Y, Vlachopapadopoulou E, Moschonis G, Karachaliou F, Psaltopoulou T, Koutsouki D, Bogdanis G, Carayanni V, Hatzakis A, Michalacos S (2016) Utility and applicability of the “Childhood Obesity Risk Evaluation” (CORE)-index in predicting obesity in childhood and adolescence in Greece from early life: the “National Action Plan for Public Health”. Eur J Pediatr 175:1989–1996CrossRefPubMedGoogle Scholar