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European Journal of Pediatrics

, Volume 175, Issue 8, pp 1129–1132 | Cite as

A neonatal prolonged QT syndrome due to maternal use of oral tricyclic antidepressants

  • Naoya Fukushima
  • Kenji Nanao
  • Hiroyuki Fukushima
  • Akira Namera
  • Masaru MiuraEmail author
Case Report

Abstract

It is known that tricyclic antidepressants induce long QT intervals associated with forms of life-threatening arrhythmia such as torsades de pointes (TdP), and these adverse effects may also occur in neonates whose mothers take tricyclic antidepressants. We report a neonatal case of prolonged QT interval and TdP caused by clomipramine that was transferred transplacentally from the mother. Administration of magnesium sulfate was effective to abolish TdP.

Conclusion: When mothers take tricyclic antidepressants during pregnancy, their newborns should be watched carefully for drug-induced long QT syndrome and TdP.

What is Known:

Tricyclic antidepressant can prolong the QT interval. It may be used for depression in pregnancy.

What is New:

This is the first neonatal case report of prolonged QT interval and TdP caused by clomipramine transferred transplacentally from the mother.

Keywords

Clomipramine Desmethylclomipramine Placental passage Prolonged QT interval Torsades de Pointes 

Abbreviations

APD

Action potential duration

EAD

Early afterdepolarizations

LQTS

Long QT syndrome

TdP

Torsades de pointes

Notes

Authors’ contributions

Naoya Fukushima wrote the paper. Naoya Fukushima and Masaru Miura revised the manuscript. Naoya Fukushima, Kenji Nanao, and Hiroyuki Fukushima were the attending pediatrician. Akira Namera performed the quantitative liquid chromatographic analysis of plasma concentrations of clomipramine and desmethylclomipramine.

Compliance with ethical standards

All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Naoya Fukushima
    • 1
  • Kenji Nanao
    • 2
  • Hiroyuki Fukushima
    • 3
  • Akira Namera
    • 4
  • Masaru Miura
    • 1
    Email author
  1. 1.Department of CardiologyTokyo Metropolitan Children’s Medical CenterFuchu-shiJapan
  2. 2.Department of PediatricsHino Municipal HospitalHino-shiJapan
  3. 3.Department of PediatricsKeio University HospitalShinjunku-kuJapan
  4. 4.Department of Forensic Medicine, Institute of Biomedical and Health SciencesHiroshima UniversityMinami-kuJapan

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