European Journal of Pediatrics

, Volume 174, Issue 10, pp 1357–1363 | Cite as

Obesity increases the risk of renal involvement in children with Henoch–Schönlein purpura

  • Yong-Li ZhaoEmail author
  • Zheng-Juan LiuEmail author
  • Xue-Mei Bai
  • Yu-Chuan Wang
  • Guo-Hua Li
  • Xue-Yan Yan
Original Article


The main aim of this study was to evaluate the relationship between obesity and renal involvement in children with Henoch–Schönlein purpura (HSP). A retrospective study of 141 pediatric patients with HSP was conducted in our hospital. The clinical data of all patients were collected from the electronic medical record management system from January 2010 to June 2014. The possible risk factors of renal involvement, especially obesity, were analyzed using univariate and multivariate analyses. Renal involvement occurred in 45/141 of the patients. A univariate analysis showed that an age more than 7 years at onset, persistent purpura, obesity, time from symptoms onset to diagnosis more than 14 days, and decreased C3 all increased the risk of renal involvement in HSP. The forward stepwise logistic regression analysis indicated obesity (odds ratio (OR) 4.43, 95 % confidence interval (CI) 1.896 to 10.358), age more than 7 years at onset (OR 2.81, 95 % CI 1.142 to 6.907), and persistent purpura (OR 2.57, 95 % CI 1.119 to 5.909) were independent risk factors for renal involvement.

Conclusions: Our results show that obesity can increase the hazard of renal involvement in children with HSP and reconfirm that older age at onset and persistent purpura are the independent risk factors for renal involvement.

What is Known:

There have been some reports that obesity was associated with the development of renal injury.

It is not clear whether obesity can increase the risk of renal involvement in children with HSP.

What is New:

The main finding of this study is that obesity can increase the hazard of renal involvement in children with HSP.


Henoch–Schönlein purpura Obesity Renal involvement Children Risk factors 



Antinuclear antibodies


Antistreptolysin O titre


Body mass index


Blood platelet count


Complement component 3


Confidence interval


C-reactive protein


Electronic medical record


Erythrocyte sedimentation rate


End-stage renal disease


Idiopathic focal segmental glomerulosclerosis


Henoch–Schönlein purpura


Mycoplasma pneumoniae antibody IgM


Odds ratio


Obesity-related glomerulopathy


Plasma fibrinogen


Reactive oxygen species


Tumor necrosis factor-α


Upper respiratory tract infection



This study is supported by a grant from the National Natural Science Found of China (No. 81402694).

Authors’ contributions

Zhao, Yong-Li did the study design, data collection, and data analysis and drafted the manuscript. Liu, Zheng-Juan did the study design and commented on and revised the final manuscript. Bai, Xue-Mei collected the data and collaborated with the drafting of the manuscript. Wang, Yu-Chuan; Li, Guo-Hua; and Yan, Xue-Yan collected the data.

Conflict of interest

All authors declare that there are no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PediatricsThe Second Affiliated Hospital of Dalian Medical UniversityDalianChina

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