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European Journal of Pediatrics

, Volume 174, Issue 10, pp 1357–1363 | Cite as

Obesity increases the risk of renal involvement in children with Henoch–Schönlein purpura

  • Yong-Li ZhaoEmail author
  • Zheng-Juan LiuEmail author
  • Xue-Mei Bai
  • Yu-Chuan Wang
  • Guo-Hua Li
  • Xue-Yan Yan
Original Article

Abstract

The main aim of this study was to evaluate the relationship between obesity and renal involvement in children with Henoch–Schönlein purpura (HSP). A retrospective study of 141 pediatric patients with HSP was conducted in our hospital. The clinical data of all patients were collected from the electronic medical record management system from January 2010 to June 2014. The possible risk factors of renal involvement, especially obesity, were analyzed using univariate and multivariate analyses. Renal involvement occurred in 45/141 of the patients. A univariate analysis showed that an age more than 7 years at onset, persistent purpura, obesity, time from symptoms onset to diagnosis more than 14 days, and decreased C3 all increased the risk of renal involvement in HSP. The forward stepwise logistic regression analysis indicated obesity (odds ratio (OR) 4.43, 95 % confidence interval (CI) 1.896 to 10.358), age more than 7 years at onset (OR 2.81, 95 % CI 1.142 to 6.907), and persistent purpura (OR 2.57, 95 % CI 1.119 to 5.909) were independent risk factors for renal involvement.

Conclusions: Our results show that obesity can increase the hazard of renal involvement in children with HSP and reconfirm that older age at onset and persistent purpura are the independent risk factors for renal involvement.

What is Known:

There have been some reports that obesity was associated with the development of renal injury.

It is not clear whether obesity can increase the risk of renal involvement in children with HSP.

What is New:

The main finding of this study is that obesity can increase the hazard of renal involvement in children with HSP.

Keywords

Henoch–Schönlein purpura Obesity Renal involvement Children Risk factors 

Abbreviations

ANA

Antinuclear antibodies

ASO

Antistreptolysin O titre

BMI

Body mass index

BPC

Blood platelet count

C3

Complement component 3

CI

Confidence interval

CRP

C-reactive protein

EMR

Electronic medical record

ESR

Erythrocyte sedimentation rate

ESRD

End-stage renal disease

FSGS

Idiopathic focal segmental glomerulosclerosis

HSP

Henoch–Schönlein purpura

MP-IgM

Mycoplasma pneumoniae antibody IgM

OR

Odds ratio

ORG

Obesity-related glomerulopathy

pFbg

Plasma fibrinogen

ROS

Reactive oxygen species

TNF-α

Tumor necrosis factor-α

URTI

Upper respiratory tract infection

Notes

Acknowledgments

This study is supported by a grant from the National Natural Science Found of China (No. 81402694).

Authors’ contributions

Zhao, Yong-Li did the study design, data collection, and data analysis and drafted the manuscript. Liu, Zheng-Juan did the study design and commented on and revised the final manuscript. Bai, Xue-Mei collected the data and collaborated with the drafting of the manuscript. Wang, Yu-Chuan; Li, Guo-Hua; and Yan, Xue-Yan collected the data.

Conflict of interest

All authors declare that there are no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PediatricsThe Second Affiliated Hospital of Dalian Medical UniversityDalianChina

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