Advertisement

European Journal of Pediatrics

, Volume 174, Issue 9, pp 1169–1174 | Cite as

The effects of maternal vitamin D on neonatal growth parameters

  • Dana Ben-Ami Shor
  • Joseph Barzel
  • Ernest Tauber
  • Howard Amital
Original Article

Abstract

Vitamin D facilitates calcium absorption and bone building. Presence of vitamin D is highly important in pregnant women due to its effect on the development of the fetal skeleton. The study population comprised 208 low-risk pregnant women of a heterogeneous population. Maternal and fetal serum concentrations of vitamin D were measured using the Liaison 25(OH)D Assay (DiaSorin, Italy).

Conclusion: Maternal vitamin D serum concentrations correlate with neonatal vitamin D serum concentrations but do not affect neonatal weight and/or head circumference.

What is known?

Vitamin D is known to be also involved in immunomodulation and cellular proliferation and differentiation.

Vitamin D is highly important in pregnant women for its effect on fetal musculoskeletal and neurological development.

What is new?

No association was detected between maternal or neonatal vitamin D concentration with neonatal growth parameters or obstetrical complications, and no association was found between maternal vitamin D serum concentrations and maternal obstetrical complication rate.

A strong correlation was demonstrated between maternal and neonatal serum vitamin D concentrations.

Keywords

Vitamin D 25(OH)D 1,25(OH)2Neonatal growth Bone metabolism 

Abbreviations

CLIA

Competitive chemiluminescence immunoassay

ng/mL

Nanograms per milliliter

nmol/L

Nanomoles per liter

VDR

Vitamin D receptor

25(OH)D

25-Hydroxyvitamin D

1,25(OH)2D

1,25-Dihydroxyvitamin D

Notes

Conflict of interest

Dana Ben-Ami Shor, Joseph Barzel, Ernest Tauber, and Howard Amital report no conflict of interest.

Author’s contributions

Dana Ben-Ami, Shor-preparation of the manuscript. Joseph Barzel, Defining concepts and aims, materialization of the study and conducting the serum samplecollection and execution of tests. Ernest Tauber, MD, Defining concepts and aims, materialization of the study design Study. Howard Amital, MD, MHA - Defining concepts and aims, materialization of the study design, preparation of the manuscript.

References

  1. 1.
    Agmon-Levin N, Theodor E, Segal RM, Shoenfeld Y (2013) Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol 45:256–266CrossRefPubMedGoogle Scholar
  2. 2.
    Amital H, Szekanecz Z, Szucs G, Danko K, Nagy E, Csepany T, Kiss E, Rovensky J, Tuchynova A, Kozakova D, Doria A, Corocher N, Agmon-Levin N, Barak V, Orbach H, Zandman-Goddard G, Shoenfeld Y (2010) Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheum Dis 69:1155–1157CrossRefPubMedGoogle Scholar
  3. 3.
    Arnson Y, Gringauz I, Itzhaky D, Amital H (2012) Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients. QJM 105:633–639CrossRefPubMedGoogle Scholar
  4. 4.
    Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM (2007) Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 92:3517–3522PubMedCentralCrossRefPubMedGoogle Scholar
  5. 5.
    Bouillon R, Van Assche FA, Van Baelen H, Heyns W, De Moor P (1981) Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest 67:589–596PubMedCentralCrossRefPubMedGoogle Scholar
  6. 6.
    Bouillon R, Van Baelen H, De Moor P (1977) 25-hydroxyvitamin D and its binding protein in maternal and cord serum. J Clin Endocrinol Metab 45:679–684CrossRefPubMedGoogle Scholar
  7. 7.
    Chiu KC, Chu A, Go VL, Saad MF (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79:820–825PubMedGoogle Scholar
  8. 8.
    Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ (2010) Vitamin D: metabolism. Endocrinol Metab Clin North Am 39:243–253, table of contentsPubMedCentralCrossRefPubMedGoogle Scholar
  9. 9.
    Cutolo M, Plebani M, Shoenfeld Y, Adorini L, Tincani A (2011) Vitamin D endocrine system and the immune response in rheumatic diseases. Vitam Horm 86:327–351CrossRefPubMedGoogle Scholar
  10. 10.
    Dawodu A, Akinbi H (2013) Vitamin D nutrition in pregnancy: current opinion. Int J Womens Health 5:333–343PubMedCentralCrossRefPubMedGoogle Scholar
  11. 11.
    Devereux G, Litonjua AA, Turner SW, Craig LC, McNeill G, Martindale S, Helms PJ, Seaton A, Weiss ST (2007) Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr 85:853–859PubMedGoogle Scholar
  12. 12.
    Diogenes ME, Bezerra FF, Rezende EP, Taveira MF, Pinhal I, Donangelo CM (2013) Effect of calcium plus vitamin D supplementation during pregnancy in Brazilian adolescent mothers: a randomized, placebo-controlled trial. Am J Clin Nutr 98:82–91CrossRefPubMedGoogle Scholar
  13. 13.
    Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F (2003) Vitamin D3 and brain development. Neuroscience 118:641–653CrossRefPubMedGoogle Scholar
  14. 14.
    Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29:21–30CrossRefPubMedGoogle Scholar
  15. 15.
    Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281CrossRefPubMedGoogle Scholar
  16. 16.
    Hollis BW (2007) Vitamin D requirement during pregnancy and lactation. J Bone Miner Res 22(Suppl 2):V39–V44CrossRefPubMedGoogle Scholar
  17. 17.
    Hollis BW, Pittard WB 3rd (1984) Evaluation of the total fetomaternal vitamin D relationships at term: evidence for racial differences. J Clin Endocrinol Metab 59:652–657CrossRefPubMedGoogle Scholar
  18. 18.
    Itzhaky D, Amital D, Gorden K, Bogomolni A, Arnson Y, Amital H (2012) Low serum vitamin D concentrations in patients with schizophrenia. Isr Med Assoc J 14:88–92PubMedGoogle Scholar
  19. 19.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, Arden NK, Godfrey KM, Cooper C (2006) Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 367:36–43CrossRefPubMedGoogle Scholar
  20. 20.
    Kaludjerovic J, Vieth R (2010) Relationship between vitamin D during perinatal development and health. J Midwifery Womens Health 55:550–560CrossRefPubMedGoogle Scholar
  21. 21.
    Ko P, Burkert R, McGrath J, Eyles D (2004) Maternal vitamin D3 deprivation and the regulation of apoptosis and cell cycle during rat brain development. Brain Res Dev Brain Res 153:61–68CrossRefPubMedGoogle Scholar
  22. 22.
    Leffelaar ER, Vrijkotte TG, van Eijsden M (2010) Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr 104:108–117CrossRefPubMedGoogle Scholar
  23. 23.
    Maghbooli Z, Hossein-Nezhad A, Karimi F, Shafaei AR, Larijani B (2008) Correlation between vitamin D3 deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 24:27–32CrossRefPubMedGoogle Scholar
  24. 24.
    Mannion CA, Gray-Donald K, Koski KG (2006) Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ 174:1273–1277PubMedCentralCrossRefPubMedGoogle Scholar
  25. 25.
    Markestad T, Aksnes L, Ulstein M, Aarskog D (1984) 25-Hydroxyvitamin D and 1,25-dihydroxyvitamin D of D2 and D3 origin in maternal and umbilical cord serum after vitamin D2 supplementation in human pregnancy. Am J Clin Nutr 40:1057–1063PubMedGoogle Scholar
  26. 26.
    McGrath JJ, Feron FP, Burne TH, Mackay-Sim A, Eyles DW (2004) Vitamin D3-implications for brain development. J Steroid Biochem Mol Biol 89–90:557–560CrossRefPubMedGoogle Scholar
  27. 27.
    Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C (2010) Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 202(429):e421–e429Google Scholar
  28. 28.
    Oren Y, Shapira Y, Agmon-Levin N, Kivity S, Zafrir Y, Altman A, Lerner A, Shoenfeld Y (2010) Vitamin D insufficiency in a sunny environment: a demographic and seasonal analysis. Isr Med Assoc J 12:751–756PubMedGoogle Scholar
  29. 29.
    Pawley N, Bishop NJ (2004) Prenatal and infant predictors of bone health: the influence of vitamin D. Am J Clin Nutr 80:1748S–1751SPubMedGoogle Scholar
  30. 30.
    Perez-Lopez FR (2007) Vitamin D: the secosteroid hormone and human reproduction. Gynecol Endocrinol 23:13–24CrossRefPubMedGoogle Scholar
  31. 31.
    Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, Soni M (2013) Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev 12:976–989CrossRefPubMedGoogle Scholar
  32. 32.
    Pludowski P, Karczmarewicz E, Bayer M, Carter G, Chlebna-Sokol D, Czech-Kowalska J, Debski R, Decsi T, Dobrzanska A, Franek E, Gluszko P, Grant WB, Holick MF, Yankovskaya L, Konstantynowicz J, Ksiazyk JB, Ksiezopolska-Orlowska K, Lewinski A, Litwin M, Lohner S, Lorenc RS, Lukaszkiewicz J, Marcinowska-Suchowierska E, Milewicz A, Misiorowski W, Nowicki M, Povoroznyuk V, Rozentryt P, Rudenka E, Shoenfeld Y, Socha P, Solnica B, Szalecki M, Talalaj M, Varbiro S, Zmijewski MA (2013) Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe—recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol 64:319–327CrossRefPubMedGoogle Scholar
  33. 33.
    Prentice A (2011) Milk intake, calcium and vitamin D in pregnancy and lactation: effects on maternal, fetal and infant bone in low- and high-income countries. Nestle Nutr Workshop Ser Pediatr Program 67:1–15CrossRefPubMedGoogle Scholar
  34. 34.
    Rosen CJ (2011) Clinical practice. Vitamin D insufficiency. N Engl J Med 364:248–254CrossRefPubMedGoogle Scholar
  35. 35.
    Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58PubMedCentralCrossRefPubMedGoogle Scholar
  36. 36.
    Sigmund CD (2002) Regulation of renin expression and blood pressure by vitamin D(3). J Clin Invest 110:155–156PubMedCentralCrossRefPubMedGoogle Scholar
  37. 37.
    Specker BL (2012) Does vitamin D during pregnancy impact offspring growth and bone? Proceed Nutri Soc 71:38–45CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Dana Ben-Ami Shor
    • 1
    • 2
  • Joseph Barzel
    • 3
  • Ernest Tauber
    • 3
  • Howard Amital
    • 1
    • 2
  1. 1.Department of Medicine ‘B’Sheba Medical CenterRamat GanIsrael
  2. 2.Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  3. 3.Department of Obstetrics and GynecologySheari-ZedekIsrael

Personalised recommendations