European Journal of Pediatrics

, Volume 174, Issue 9, pp 1169–1174 | Cite as

The effects of maternal vitamin D on neonatal growth parameters

  • Dana Ben-Ami Shor
  • Joseph Barzel
  • Ernest Tauber
  • Howard Amital
Original Article


Vitamin D facilitates calcium absorption and bone building. Presence of vitamin D is highly important in pregnant women due to its effect on the development of the fetal skeleton. The study population comprised 208 low-risk pregnant women of a heterogeneous population. Maternal and fetal serum concentrations of vitamin D were measured using the Liaison 25(OH)D Assay (DiaSorin, Italy).

Conclusion: Maternal vitamin D serum concentrations correlate with neonatal vitamin D serum concentrations but do not affect neonatal weight and/or head circumference.

What is known?

Vitamin D is known to be also involved in immunomodulation and cellular proliferation and differentiation.

Vitamin D is highly important in pregnant women for its effect on fetal musculoskeletal and neurological development.

What is new?

No association was detected between maternal or neonatal vitamin D concentration with neonatal growth parameters or obstetrical complications, and no association was found between maternal vitamin D serum concentrations and maternal obstetrical complication rate.

A strong correlation was demonstrated between maternal and neonatal serum vitamin D concentrations.


Vitamin D 25(OH)D 1,25(OH)2Neonatal growth Bone metabolism 



Competitive chemiluminescence immunoassay


Nanograms per milliliter


Nanomoles per liter


Vitamin D receptor


25-Hydroxyvitamin D


1,25-Dihydroxyvitamin D


Conflict of interest

Dana Ben-Ami Shor, Joseph Barzel, Ernest Tauber, and Howard Amital report no conflict of interest.

Author’s contributions

Dana Ben-Ami, Shor-preparation of the manuscript. Joseph Barzel, Defining concepts and aims, materialization of the study and conducting the serum samplecollection and execution of tests. Ernest Tauber, MD, Defining concepts and aims, materialization of the study design Study. Howard Amital, MD, MHA - Defining concepts and aims, materialization of the study design, preparation of the manuscript.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Dana Ben-Ami Shor
    • 1
    • 2
  • Joseph Barzel
    • 3
  • Ernest Tauber
    • 3
  • Howard Amital
    • 1
    • 2
  1. 1.Department of Medicine ‘B’Sheba Medical CenterRamat GanIsrael
  2. 2.Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael
  3. 3.Department of Obstetrics and GynecologySheari-ZedekIsrael

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