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European Journal of Pediatrics

, Volume 174, Issue 6, pp 791–799 | Cite as

Motor performance in children and adolescents with cancer at the end of acute treatment phase

  • Miriam GötteEmail author
  • Sabine V. Kesting
  • Corinna C. Winter
  • Dieter Rosenbaum
  • Joachim Boos
Original Article

Abstract

Reduced motor performance may particularly limit reintegration into normal life after cessation of treatment in pediatric cancer patients. This study aimed at analyzing motor performance at the end of the acute treatment phase and reveals potential risk factors for motor deficits. A childhood cancer population with different tumor entities was assessed with the MOON test, which allows for comparison with age- and gender-matched reference values of healthy children, at the end of the acute treatment phase. Forty-seven patients were tested at 7.0 ± 2.6 months after diagnosis. Significant reductions of motor performance affected muscular explosive strength (P < 0.001), handgrip strength (P < 0.001), muscular endurance of legs (P = 0.035), hand-eye coordination (P < 0.001), static balance (P = 0.003), speed (P = 0.012), and flexibility (P < 0.001). Loss of upper extremity coordination did not achieve statistical significance. Associations between single motor deficits and the tumor entity, age, body mass index, and inactivity during treatment were revealed, whereas no associations were found for gender and vincristine application.

Conclusion: Overall, motor performance was low in the patient group studied. We recommend that individualized exercise interventions to attenuate motor deficits and promote physical activity are needed during cancer treatment in order to enhance motor performance and improve social participation during and after cancer therapy.

Keywords

Motor performance Pediatric cancer patients Physical activity Exercise Acute treatment 

Abbreviations

ALL

Acute lymphoblastic leukemia

AML

Acute myeloid leukemia

BMI

Body mass index

MOON

Test for motor performance in pediatric oncology

Notes

Acknowledgments

This study was funded by the Cora-Lobscheid Foundation. The authors would like to thank all the children and adolescents who participated in this study and Gabriele Braun-Munzinger for her writing assistance.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The study was approved by the local ethics committee and is therefore in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All patients and legal guardians gave their informed consent prior to their inclusion to the study.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Miriam Götte
    • 1
    Email author
  • Sabine V. Kesting
    • 1
  • Corinna C. Winter
    • 2
  • Dieter Rosenbaum
    • 2
  • Joachim Boos
    • 1
  1. 1.Department of Pediatric Hematology and OncologyUniversity Hospital of MünsterMünsterGermany
  2. 2.Movement Analysis Lab, Institute for Experimental Musculoskeletal MedicineUniversity Hospital of MünsterMünsterGermany

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