European Journal of Pediatrics

, Volume 174, Issue 2, pp 177–181 | Cite as

Intermittent versus continuous phototherapy for the treatment of neonatal non-hemolytic moderate hyperbilirubinemia in infants more than 34 weeks of gestational age: a randomized controlled trial

  • Monica Sachdeva
  • Srinivas Murki
  • Tejo Pratap OletiEmail author
  • Hemasree Kandraju
Original Article


Intermittent phototherapy with “12 h on and then 12 h off” schedule in comparison with continuous phototherapy for neonatal hyperbilirubinemia may save costs and decrease anxiety of parents. In this non-inferiority-randomized controlled trial, healthy late preterm (>34 weeks) and term neonates with neonatal hyperbilirubinemia under phototherapy for 8 h and total serum bilirubin (TSB) < 18 mg/dL were randomized either into intermittent (IPT) or continuous (CPT) group. Infants in IPT group received 12 h on and 12 h off cycles of phototherapy. In both arms, phototherapy was continued until TSB < 13 mg/dL. Primary outcome was rate of fall of bilirubin. Seventy-five infants (IPT n = 36 vs. CPT n = 39) were enrolled in the study. The rate of fall of bilirubin was significantly higher with “IPT” phototherapy (p = 0.002). Conclusion: In term and late preterm infants with non-hemolytic moderate hyperbilirubinemia, intermittent phototherapy with 12 h on and 12 h off cycles is as efficacious as continuous phototherapy.


Phototherapy Moderate hyperbilirubinemia Intermittent Day care Neonate 



Compact fluorescent lamps


Continuous phototherapy


Intermittent phototherapy


Intention to treat analysis


Light emission diode




Total serum bilirubin


Conflict of interest

The authors declare no conflict of interest.

Financial assistance


Supplementary material

431_2014_2373_MOESM1_ESM.docx (36 kb)
ESM 1 (DOCX 35 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Monica Sachdeva
    • 1
  • Srinivas Murki
    • 1
  • Tejo Pratap Oleti
    • 1
    Email author
  • Hemasree Kandraju
    • 1
  1. 1.Department of PediatricsFernandez HospitalHyderabadIndia

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