Intermittent versus continuous phototherapy for the treatment of neonatal non-hemolytic moderate hyperbilirubinemia in infants more than 34 weeks of gestational age: a randomized controlled trial
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Intermittent phototherapy with “12 h on and then 12 h off” schedule in comparison with continuous phototherapy for neonatal hyperbilirubinemia may save costs and decrease anxiety of parents. In this non-inferiority-randomized controlled trial, healthy late preterm (>34 weeks) and term neonates with neonatal hyperbilirubinemia under phototherapy for 8 h and total serum bilirubin (TSB) < 18 mg/dL were randomized either into intermittent (IPT) or continuous (CPT) group. Infants in IPT group received 12 h on and 12 h off cycles of phototherapy. In both arms, phototherapy was continued until TSB < 13 mg/dL. Primary outcome was rate of fall of bilirubin. Seventy-five infants (IPT n = 36 vs. CPT n = 39) were enrolled in the study. The rate of fall of bilirubin was significantly higher with “IPT” phototherapy (p = 0.002). Conclusion: In term and late preterm infants with non-hemolytic moderate hyperbilirubinemia, intermittent phototherapy with 12 h on and 12 h off cycles is as efficacious as continuous phototherapy.
KeywordsPhototherapy Moderate hyperbilirubinemia Intermittent Day care Neonate
Compact fluorescent lamps
Intention to treat analysis
Light emission diode
Total serum bilirubin
Conflict of interest
The authors declare no conflict of interest.
- 7.McDonagh AF (1983) Mechanism of action of phototherapy. In: Levine RL, Maisels MJ (eds) Hyperbilirubinaemia in the newborn. Report of the eighty-fifth Ross Conference on Pediatric Research. Ross Laboratory, Columbus, pp 47–53Google Scholar