Preterm infants with severe extrauterine growth retardation (EUGR) are at high risk of growth impairment during childhood
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Extrauterine growth retardation (EUGR) seriously affects premature newborns and is related to the impairment of growth during childhood. There are very limited data available concerning the growth outcome of EUGR children. Our aim was to assess the growth outcome in a cohort of children born before 34 weeks of gestation with severe EUGR. This was a retrospective multicenter study, performed in outpatient endocrinology clinic. A total of 103 premature children with weight and/or length below −2 standard deviation score (SDS) of “intrauterine” growth expectation at the time of discharge from hospital (within 42 weeks of postmenstrual age) were included in the study. The study participants underwent a thorough anthropometric assessment at a mean age of 3.9 years ± 1.7 SD. Of the EUGR children, 12.6 % showed a height below −2 SDS and 7.7 % even below −2.5 SDS. Growth impairment was more common in males than in females (17 vs. 8 %). The prevalence of subnormal weight (below −2 SDS) was 13.6 %, being higher in males than in females (17 vs. 10 %). BMI values below −2 SDS were found in 18.4 % of our study population (22.7 % in males and 12 % in females). The 19.6 % of EUGR children did not catch up in head circumference during early childhood. Length at term was the major predictor of height in childhood (P < 0.001). Conclusion: A significant proportion of children born prematurely with severe EUGR show growth retardation in childhood thus suggesting the need for a close clinical follow-up to determine their growth potential and implement effective intervention strategies.
KeywordsExtrauterine growth retardation Growth Low birth weight
Appropriate for gestational age
Birth crown-heel length
Body mass index
Extremely low birth weight
Extrauterine growth restriction
Neonatology intensive care unit
Standard deviation score
Small for gestational age
Very low birth weight
This study was generously supported by Pfizer grant.
Conflict of interest
The authors declare that they have no competing interests.
- 2.Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379:2162–2172PubMedCrossRefGoogle Scholar
- 11.Festen DA, de Lind van Wijngaarden R, van Eekelen M, Otten BJ, Wit JM, Duivenvoorden HJ et al (2008) Randomized controlled GH trial: effects on anthropometry, body composition and body proportions in a large group of children with Prader-Willi syndrome. Clin Endocrinol (Oxf) 69:443–451CrossRefGoogle Scholar
- 12.Finken MJ, Dekker FW, de Zegher F, Wit JM (2006) Dutch project on preterm and small-for-gestational-age-19 collaborative study group. Long-term height gain of prematurely born children with neonatal growth restraint: parallellism with the growth pattern of short children born small for gestational age. Pediatrics 118:640–643PubMedCrossRefGoogle Scholar
- 20.Lemons JA, Bauer CR, Oh W, Korones SB, Papile LA, Stoll BJ et al (2001) Very low birth weight outcomes of the national institute of child health and human development neonatal research network, January 1995 through, December 1996 NICHD neonatal research network. Pediatrics 107:E1PubMedCrossRefGoogle Scholar
- 30.WHO Multicentre Growth Reference Study Group (2007) WHO Child Growth Standards: head circumference-for-age, arm circumference-for-age, triceps skinfold-for-age and subscapular skinfold-for-age: methods and development. World Health Organization, GenevaGoogle Scholar
- 31.Wit JM, Finken MJ, Rijken M, de Zegher F (2006) Preterm growth restraint: a paradigm that unifies intrauterine growth retardation and preterm extrauterine growth retardation and has implications for the small-for-gestational-age indication in growth hormone therapy. Pediatrics 117:e793–e795PubMedCrossRefGoogle Scholar