European Journal of Pediatrics

, Volume 172, Issue 8, pp 1039–1042

Comparison between daily supplementation doses of 200 versus 400 IU of vitamin D in infants

  • Erman Atas
  • Ferhan Karademır
  • Atilla Ersen
  • Cihan Meral
  • Secil Aydınoz
  • Selami Suleymanoglu
  • Mustafa Gultepe
  • İsmail Gocmen
Original Article


The daily supplementation of vitamin D is mandatory for infants. However, there are still conflicting opinions about the exact daily dose. Thus, we aimed to evaluate a daily supplementation dose of 200 IU is sufficient and compared the supplementation doses of 200 and 400 IU per day. One hundred and sixty-nine infants were randomly assigned to two groups (group1, 200 IU/day; group 2, 400 IU/day) and there were 75 infants in group 1 and 64 were in group 2 with a total number of 139. The median levels of 25-hydroxyvitamin D3 were significantly increased in group 2 at the age of 4 months (group 1, 39.60 mcg/L; group 2, 56.55 mcg/L; p < 0.0001). We clearly demonstrated that at the age of 4 months, none of the infants on the group 2 had a serum level of 25-hydroxyvitamin D3 less than 30 mcg/L. However, 21.3 % of the infants in group 1 had a level below 30 mcg/L. Thus, in order to avoid vitamin D deficiency and rickets, we recommend supplementation dose of vitamin D at 400 IU/day as a safe and effective dose.


Vitamin D Infants Supplementation Dose 



25-Hydroxyvitamin D3


Vitamin D


Vitamin D supplementation


High-performance liquid chromatography


1,25-Hydroxyvitamin D3


The American Academy of Pediatrics


European Society for Paediatric Endocrinology


Vitamin D deficiency


Vitamin D insufficency


Vitamin D sufficiency


Severe vitamin D deficiency


Estimated average requirement


Recommended dietary allowance


The Institute of Medicine


The tolerable upper intake limit


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Erman Atas
    • 1
  • Ferhan Karademır
    • 2
  • Atilla Ersen
    • 3
  • Cihan Meral
    • 2
  • Secil Aydınoz
    • 2
  • Selami Suleymanoglu
    • 2
  • Mustafa Gultepe
    • 4
  • İsmail Gocmen
    • 2
  1. 1.Department of Pediatric OncologyGulhane Military Medical AcademyAnkaraTurkey
  2. 2.PediatricsHaydarpasa Hospital of Gulhane Military Medical AcademyIstanbulTurkey
  3. 3.PediatricsKasimpasa Military HospitalIstanbulTurkey
  4. 4.BiochemistryHaydarpasa Hospital of Gulhane Military Medical AcademyIstanbulTurkey

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