European Journal of Pediatrics

, Volume 172, Issue 6, pp 769–774 | Cite as

Urinary concentration of cytokines in children with acute pyelonephritis

  • Yakubov Renata
  • Hassan Jassar
  • Rina Katz
  • Amit Hochberg
  • Rony-Reuven Nir
  • Adi Klein-KremerEmail author
Original Article


Urinary tract infection (UTI) is a common bacterial infection among infants and children. Predicting which children with upper UTI will develop long-term sequelae remains difficult. We aimed at evaluating the predictive value of urine concentrations of interleukin-6 (UIL-6) and interleukin-8 (UIL-8) in subsequent renal scarring. In the current observational prospective study, urine samples for UIL-6 and UIL-8 were obtained from two groups: 31 children with first episode of febrile UTI and 22 febrile children of other origin. UIL-6 and UIL-8 were increased in children with febrile UTI, compared to children with fever of other origin [median and range (picograms per milliliter): (1) UIL-6, 74.46 (0–168) vs. 10.51 (0–47.50), respectively, p = 0.0001; (2) UIL-8, 2,660.38 (0–13,801) vs. 0, respectively, p = 0.0001]. Renal scarring was found in 5/31 (16 %) children with acute pyelonephritis. Initial median UIL-8 values were significantly higher in children with later renal scarring than in those without renal scarring [median and range (picograms per milliliter): 6,163 (2,021–13,801) vs. 1,490.5 (0–5,737), respectively, p = 0.018]. In conclusion, UIL-8 might serve as a predictive biomarker for renal scarring after an acute episode of pyelonephritis. Since UIL-8 emerges as a renal-specific diagnostic and prognostic marker, it may be suitable as a selective screening tool for children with febrile UTI.


Urinary tract infection Urinary interleukins Biomarkers Renal scarring 


Conflict of interest

None declared.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Yakubov Renata
    • 1
  • Hassan Jassar
    • 1
  • Rina Katz
    • 2
  • Amit Hochberg
    • 1
  • Rony-Reuven Nir
    • 3
  • Adi Klein-Kremer
    • 1
    Email author
  1. 1.Pediatrics DepartmentHillel Yaffe Medical CenterHaderaIsrael
  2. 2.Laboratory of Clinical Immunology and Tissue Typing, Rambam Health Care CampusHaifaIsrael
  3. 3.The Ruth and Bruce Rappaport Faculty of MedicineTechnion–Israel Institute of TechnologyHaifaIsrael

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