Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium-adsorbed vaccines—prognosis and outcome after booster vaccination
Persistent itching subcutaneous nodules and aluminium (Al) allergy have been described after vaccination with Al-adsorbed vaccines but are considered rare. Little is known about the prognosis. Sixty-four children with itching nodules following vaccination with diphtheria–tetanus–pertussis (DTP) vaccines currently used in Sweden (Infanrix® and Pentavac®) were spontaneously reported to the authors from 1999 and followed for up to 12 years. The median duration of itching was 5 years in the 44 children who were free or almost free from symptoms at the latest follow-up. Typical findings were a long interval between vaccination and onset of symptoms (months or years) and intensified itching during intercurrent infections. Contact allergy to aluminium was demonstrated in 60/63 children (95 %). Neither the incidence nor differences between the two vaccines can be estimated from this study, but vaccine-induced itching nodules are probably more common than hitherto realised. The median interval between onset of symptoms and diagnosis was 8 months in a region where nurses were educated to recognise the condition compared to 2 years in other regions. Booster vaccination with DTP-polio was postponed or declined by 15/40 families in fear for new problems. Out of 25 children who received a booster dose, only two had new itching nodules. Conclusion: Intensely itching subcutaneous nodules (vaccination granulomas) and contact allergy to aluminium may occur after primary vaccination with the two most commonly used DTP vaccines in Europe. The condition is probably underreported. Symptoms may last for at least 4–5 years but eventually seem to subside.
KeywordsItching nodule Granuloma Contact allergy Aluminium Adjuvant Vaccines
- 2.Beck MH, Wilkinson SM (2004) Contact dermatitis: allergic contact dermatitis to specific allergens. In: Burns T, Breathnach S, Cox N, Griffiths C (eds) Rook’s textbook of dermatology, 7th edn. Blackwell Science, Oxford. Vol. 1, Chapter 20, p. 47Google Scholar
- 37.Wahlberg JE (1991) Patch testing. In: Rycroft RJG, Menné T, Frosch PJ, Benezra C (eds) Textbook of contact dermatitis. Springer, Berlin, pp 241–264Google Scholar