European Journal of Pediatrics

, Volume 171, Issue 12, pp 1793–1798 | Cite as

Status of vitamin D in children with sickle cell disease living in Madrid, Spain

  • Carmen GarridoEmail author
  • Elena Cela
  • Cristina Beléndez
  • Cristina Mata
  • Jorge Huerta
Original Article


Patients with sickle cell disease have vitamin D deficiency and poor bone health which makes them prone to have an increased risk of fractures and osteoporosis in adulthood. We performed a prospective, cross-sectional study in children diagnosed with sickle cell disease living in Madrid, Spain. The purpose of this study was to evaluate the status of vitamin D of these children. Patients 0–16 years old were enrolled between 2008 and 2011. We studied demographics, calcium metabolism, and bone health, especially by measuring levels of 25-hydroxyvitamin D (25(OH)D), during different seasons of the year, and bone densitometry (beyond 4 years of age). Seventy-eight children were included in the study. Mean age was 4.8 ± 4.3 years, and mean serum 25(OH)D level was 21.50 ± 13.14 ng/ml, with no differences in 25(OH)D levels within different seasons. Fifty-six percent of children had levels of 25(OH) vitamin D of <20 ng/ml, whereas 79 and 18 % of them had levels of <30 and <11 ng/ml, respectively. Secondary hyperparathyroidism was observed in 25 % of children. Densitometry was performed in 33 children, and an abnormal z-score was seen in 15.2 % of them with no correlation with levels of 25(OH)D. Conclusions: Vitamin D deficiency is highly prevalent in children with sickle cell disease, who are residing in Madrid, Spain, and it is detected at a young age. We propose that early intervention may increase the possibility of an adequate bone density later in life.


Sickle cell disease Vitamin D deficiency 25-Hydroxyvitamin D 



The authors would like to thank Dr. Cynthia McCoig and Dr. Jesús Saavedra-Lozano for reviewing the manuscript.

Conflict of interest



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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Carmen Garrido
    • 1
    Email author
  • Elena Cela
    • 1
  • Cristina Beléndez
    • 1
  • Cristina Mata
    • 1
  • Jorge Huerta
    • 1
  1. 1.Division of Pediatric Hematology and Oncology, Department of Pediatrics MedicineHospital General Universitario Gregorio MarañónMadridSpain

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