European Journal of Pediatrics

, Volume 171, Issue 9, pp 1409–1411

Kikuchi–Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis

  • Toru Watanabe
  • Hideki Hashidate
  • Yutaka Hirayama
  • Yasushi Iinuma
Case Report

DOI: 10.1007/s00431-012-1729-1

Cite this article as:
Watanabe, T., Hashidate, H., Hirayama, Y. et al. Eur J Pediatr (2012) 171: 1409. doi:10.1007/s00431-012-1729-1

Abstract

Kikuchi–Fujimoto disease (KFD) is a benign and self-limited syndrome, characterized by regional lymphadenopathy and fever. Although the pathogenesis of KFD remains unclear, infectious agents, autoimmune causes, and physicochemical factors have been suggested as triggers. However, KFD following vaccination has never been reported. We present a 14-year-old girl who suffered from fever and cervical lymph node swelling following simultaneous administration of human papilloma virus vaccine and Japanese encephalitis virus vaccine. The patient was diagnosed with KFD based on the histopathologic findings of a lymph node biopsy, and her fever and swelling resolved with oral corticosteroid therapy. Although the exact pathogenesis of the development of KFD following immunization remains unknown, this should be added to the list of potential triggers or factors associated with the development of KFD.

Keywords

Kikuchi’s disease Vaccine Histiocytic necrotizing lymphadenitis Adverse events Vaccination complication 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Toru Watanabe
    • 1
  • Hideki Hashidate
    • 2
  • Yutaka Hirayama
    • 3
  • Yasushi Iinuma
    • 3
  1. 1.Department of PediatricsNiigata City General HospitalNiigata CityJapan
  2. 2.Department of PathologyNiigata City General HospitalNiigata CityJapan
  3. 3.Department of Pediatric SurgeryNiigata City General HospitalNiigata CityJapan

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