European Journal of Pediatrics

, Volume 171, Issue 4, pp 735–736 | Cite as

Iatrogenic Cushing syndrome due to nasal steroid drops

  • Veysel Nijat BaşEmail author
  • Semra Çetinkaya
  • Zehra Aycan
Case Report


Iatrogenic Cushing syndrome may occur as an undesirable outcome of high-dose glucocorticoids treatments. This may also cause hypothalamus–hypophysis–adrenal axis suppression. While this situation may be caused more frequently with oral and topical glucocorticoid therapy, iatrogenic Cushing syndrome in childhood, caused by steroid-containing nasal drops, is a rare event. Hereby, we present a baby who developed iatrogenic Cushing syndrome induced by long-term use of steroid-containing nasal drops for choanal atresia. In conclusion, the serious side effects of the nasal drops should have been explained to the family, and their long-term use should have been refrained.


Cushing syndrome Nasal steroids 


Conflict of interest

The authors declare no conflict of interest related to this work and do not have a financial relationship with the organization that sponsored the research.


  1. 1.
    Arı ME, Çetinkaya S, Tüfekçi BS, Takçı Ş, Nazlıer K (2009) Olgu Sunumu: Topikal Steroid Kullanımına İkincil Cushing Sendromu. Turkish J Pediatr Dis 3:48–52Google Scholar
  2. 2.
    Baş VN, Çetinkaya S, Yılmaz Ağladıoğlu S, Peltek Kendirci HN, Aycan Z (2010) Topikal Steroide Bağlı İyatrojenik Cushing Sendromu. J Child 2010(10):152–155Google Scholar
  3. 3.
    Boscaro M, Barzon L, Fallo F, Sonino N (2001) Cushing's syndrome. Lancet 357:783–791PubMedCrossRefGoogle Scholar
  4. 4.
    Kibar E, Soy D, Aycan Z, Çetinkaya E (2009) Topikal Steroide Sekonder İatrojenik Cushing Sendromu. Turkish J Pediatr Dis 1:44–48Google Scholar
  5. 5.
    Kimmerle R, Rolla AR (1985) Iatrogenic Cushing’s syndrome due to dexamethasone nasal drops. Am J Med 79:535–537PubMedCrossRefGoogle Scholar
  6. 6.
    Miller WL (2009) The adrenal cortex and its disorders. In: Brook CGD, Clayton PE, Brown RS (eds) Brook's clinical pediatric endocrinology, 6th edn. Wiley-Blackwell, Oxford, pp 283–326Google Scholar
  7. 7.
    Nur B, Karagüzel G, Türkkahraman D, Akçurin S, Bircan İ (2007) Topikal steroid kullanımına bağlı iyatrojenik Cushing sendromu: İki vakanın takdimi. Turkish Pediatr J 50:125–128Google Scholar
  8. 8.
    Root AW, Shulman DI (2004) Clinical adrenal disorders. In: Pescovitz OH, Eugster EA (eds) Pediatric endocrinology. Lippincott Williams and Wilkins, Philadelphia, pp 568–600Google Scholar
  9. 9.
    Turpeinen M, Salo OP, Leisti S (1986) Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease. Br J Dermatol 115:475–484PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Veysel Nijat Baş
    • 1
    Email author
  • Semra Çetinkaya
    • 1
  • Zehra Aycan
    • 1
  1. 1.Clinics of Pediatric EndocrinologyDr. Sami Ulus Research and Training Hospital of Women’s and Children’s Health and DiseasesAnkaraTurkey

Personalised recommendations