European Journal of Pediatrics

, Volume 170, Issue 12, pp 1597–1602 | Cite as

Lane-Hamilton syndrome: case report and review of the literature

  • Guy F. M. HendrickxEmail author
  • Katia Somers
  • Yvan Vandenplas
Short Report


We report a case of a three-and-a-half-year-old boy, who presented with poor general condition, stunted growth, had the presence of nail clubbing, persistent cough and frequent diarrhoea. Persistent iron deficiency anaemia without signs of haemolysis suggested Lane-Hamilton syndrome (LHS) which is or/is an extremely rare combination of idiopathic pulmonary haemosiderosis (IPH) and celiac disease (CD), although both diseases are immunologically mediated and the pathogenetic link between them is not clear. We have now 3 years of follow-up on gluten-free diet (GFD), resulting in a gradual recovery of the abnormal laboratory results in combination with an improving growth. Clinically, he is asymptomatic without any additional treatment. Our case illustrates that CD should be specifically looked for in patients with IPH, especially those in whom the severity of anaemia is disproportionate to the IPH symptoms. Both diseases may benefit from a GFD.


Celiac disease Idiopathic pulmonary haemosiderosis Lane-Hamilton syndrome 



Antinuclear antibody


Antineutrophil cytoplasm antibodies


Glomerular basement membrane antibodies


Anti-tissue transglutaminase


Celiac disease


Gluten-free diet


High-resolution CT


Intraepithelial lymphocytes


Idiopathic pulmonary haemosiderosis


Lane-Hamilton syndrome



We would like to thank Dr. Beyers Oosthuizen for the review of and comments on our manuscript.

Conflict of interest statement

All authors state that there is no conflict of interests.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Guy F. M. Hendrickx
    • 1
    • 2
    Email author
  • Katia Somers
    • 3
  • Yvan Vandenplas
    • 1
  1. 1.UZ kinderziekenhuis BrusselBrusselBelgium
  2. 2.Department of PaediatricsSint AnnakliniekGeldropThe Netherlands
  3. 3.Laboratorium voor PathologieStichting PAMMEindhovenThe Netherlands

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