European Journal of Pediatrics

, Volume 170, Issue 10, pp 1309–1316 | Cite as

Lipoprotein lipase gene polymorphisms and risks of childhood obesity in Chinese preschool children

  • Li N. Wang
  • Qing Yu
  • Yan Xiong
  • Lin F. Liu
  • Zhen Zhang
  • Xue N. Zhang
  • Hao Cheng
  • Bei Wang
Original Paper


Childhood obesity is increasingly prevalent in the community and is related to many adult diseases. Lipoprotein lipase (LPL) plays a central role in dyslipidemia, and polymorphisms of the LPL gene may result in the disturbance in the lipid’s metabolism. The aim of this study is to test the hypothesis that genetic variants of LPL and serum lipid levels are associated with the risk of childhood obesity. We genotyped +495T > G and PvuII T > C in an LPL gene and measured the serum lipid levels in a case–control study of 124 obese children and 346 frequency-matched normal controls in preschool Chinese children. The variant genotypes of LPL +495GG and PvuII CC were associated with a significantly increased risk of childhood obesity [adjusted odds ratio (OR) = 2.39, 95% CI = 1.09–5.23 for +495 GG; adjusted OR = 2.00, 95% CI = 1.04–3.83 for PvuII CC], compared with their wild-type genotypes, respectively. In addition, compared with the lower serum level cut off by the control median, the higher level of serum triglyceride (TG) (>0.59 mmol/L) was associated with a 1.32-fold increased risk of childhood obesity, and the higher level of high density lipoprotein cholesterol (HDLC) (>1.14 mmol/L) was associated with a 36% decrease in risk of childhood obesity. Furthermore, the median levels of TG were higher in obese children carrying LPL +495TT/TG and PvuII TT/CT genotypes than those in controls, the HDLC levels were lower in obese children carrying LPL +495TG and PvuII CT/CC genotypes than those in controls. In conclusion, the LPL gene +495T > G and PvuII T > C polymorphisms may modulate the magnitude of dyslipidemia in Chinese early-onset obesity.


Lipoprotein lipase Genetic polymorphisms Childhood obesity Molecular epidemiology 



Lipoprotein lipase


Total cholesterol




High density lipoprotein cholesterol


Low density lipoprotein cholesterol


Linkage disequilibrium


Single nucleotide polymorphism


Odds ratio


Confidence interval


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Li N. Wang
    • 1
  • Qing Yu
    • 2
  • Yan Xiong
    • 3
  • Lin F. Liu
    • 2
  • Zhen Zhang
    • 1
  • Xue N. Zhang
    • 1
  • Hao Cheng
    • 1
  • Bei Wang
    • 1
  1. 1.Department of Epidemiology and Biostatistics, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public HealthSoutheast UniversityNanjingChina
  2. 2.Huai’an Centre for Disease Control and PreventionHuai’an CityChina
  3. 3.Baixia District Centre for Disease Control and PreventionNanjingChina

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