The effect of vitamin A on renal damage following acute pyelonephritis in children
- 270 Downloads
Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency of renal scars (Kavukçu et al., BJU Int 83(9):1055–1059, 1999). The aim of this study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2–144), with first-time pyelonephritis verified by an uptake defect on acute dimercaptosuccinic acid (DMSA) scan were included in the study and randomly allocated to the case or control groups. All were given intravenous ceftriaxone for 10 days followed by oral cephalexin for 3 months. Cases in addition were given a single intramuscular dose of vitamin A, 25,000 U for infants below 1 year of age and 50,000 U for older children. At the repeat DMSA scan after 3 months, five of 25 cases (20%) and 17 of 25 controls (68%) had abnormal findings (p = 0.001). In conclusion, administration of vitamin A was associated with a significantly lower rate of permanent renal damage.
KeywordsAcute pyelonephritis Children Renal scar Vitamin A
We would like to thank our colleagues including Dr. A Barikani, Dr. N Esmailzadehha, Ms. J Pourrezaei, and the staff of the Center for Clinical Researches at Qazvin Children Hospital, affiliated to Qazvin University of Medical Sciences. Our appreciation also goes to Dr. A.A Pahlevan for his cooperation. This research was officially registered as project No. 718 at the College of Medicine, Qazvin University of Medical Sciences.
Conflict of interest
There is no conflict of interest (we did not have any financial relationship).
- 1.Ayazi P, Mahyar A, Jahani Hashemi H et al (2009) Comparison of procalcitonin and C-reactive protein tests in children with urinary tract infection. Iran J Pediatr 19(4):381–386Google Scholar
- 2.Bahat E, Yilmaz GG, Akman S et al (1998) Effect of vitamin A supplementation on recurrent urinary tract infections in children (abstract). Pediatr Nephrol 12:C 129Google Scholar
- 4.Bloch CE (1924) Further clinical investigations into the diseases arising in consequence of a deficiency in the fat-soluble A factor. Am J Dis Child 28(6):659–667Google Scholar
- 19.Kliegman RM, Behrman RE, Jenson HB, Stanton BF (2007) Nelson textbook of pediatrics, 18th edn. Saunders, Philadelphia, pp 2223–2228Google Scholar