European Journal of Pediatrics

, Volume 170, Issue 3, pp 347–350 | Cite as

The effect of vitamin A on renal damage following acute pyelonephritis in children

  • Parviz AyaziEmail author
  • Seyed Alireza Moshiri
  • Abolfazl Mahyar
  • Mona Moradi
Original Paper


Animal studies suggest that administration of vitamin A to rats with experimental urinary tract infection decreases the frequency of renal scars (Kavukçu et al., BJU Int 83(9):1055–1059, 1999). The aim of this study was to determine the effect of vitamin A on the rate of permanent renal damage in children with acute pyelonephritis. Fifty children, median age of 24 months (range 2–144), with first-time pyelonephritis verified by an uptake defect on acute dimercaptosuccinic acid (DMSA) scan were included in the study and randomly allocated to the case or control groups. All were given intravenous ceftriaxone for 10 days followed by oral cephalexin for 3 months. Cases in addition were given a single intramuscular dose of vitamin A, 25,000 U for infants below 1 year of age and 50,000 U for older children. At the repeat DMSA scan after 3 months, five of 25 cases (20%) and 17 of 25 controls (68%) had abnormal findings (p = 0.001). In conclusion, administration of vitamin A was associated with a significantly lower rate of permanent renal damage.


Acute pyelonephritis Children Renal scar Vitamin A 



We would like to thank our colleagues including Dr. A Barikani, Dr. N Esmailzadehha, Ms. J Pourrezaei, and the staff of the Center for Clinical Researches at Qazvin Children Hospital, affiliated to Qazvin University of Medical Sciences. Our appreciation also goes to Dr. A.A Pahlevan for his cooperation. This research was officially registered as project No. 718 at the College of Medicine, Qazvin University of Medical Sciences.

Conflict of interest

There is no conflict of interest (we did not have any financial relationship).


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Parviz Ayazi
    • 1
    Email author
  • Seyed Alireza Moshiri
    • 2
  • Abolfazl Mahyar
    • 3
  • Mona Moradi
    • 4
  1. 1.Department of Pediatric Infectious Diseases, Clinical Research Center, Qazvin Children HospitalQazvin University of Medical SciencesQazvinIran
  2. 2.Department of Pediatric NephrologyQazvin University of Medical SciencesQazvinIran
  3. 3.Department of PediatricQazvin University of Medical SciencesQazvinIran
  4. 4.Emergency Department of PediatricQazvin University of Medical SciencesQazvinIran

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