European Journal of Pediatrics

, Volume 170, Issue 1, pp 75–80 | Cite as

Association between height and weight catch-up growth with insulin resistance in pre-pubertal Chinese children born small for gestational age at two different ages

  • Hong-Zhu Deng
  • Yan-Hong Li
  • Zhe Su
  • Hua-Mei Ma
  • Yue-Fang Huang
  • Hong-Shan Chen
  • Min-Lian Du
Original Paper

Abstract

This study was performed to test whether children born small for gestational age (SGA) with catch-up growth (CUG) could be associated with the early development of insulin resistance and the β-cell dysfunction and to explore the impacts of height CUG and weight CUG on the insulin resistance in a Chinese population. A total of 30 children born SGA with CUG, 37 non-CUG (NCUG), and 42 born appropriate for gestational age (AGA) with normal height were recruited. Their fasting serum insulin, fasting glucose, insulin-like growth factor-1 (IGF-1) concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) and β-cell function (HOMA%) were evaluated. The values of HOMA-IR in CUG SGA were significantly higher than that in NCUG SGA (P = 0.002) and AGA children (P = 0.036), respectively. Correlation analysis revealed that the concentrations of fasting serum insulin were positively correlated with IGF-1 (r = 0.443, P = 0.001) and Δheight standard deviation score (SDS; r = 0.500, P = 0.002) in ≤6-year-old SGA children, but only with Δweight SDS (r = 0.496, P = 0.030) in >6-year-old children. In conclusion, SGA children with CUG in height and a higher body mass index are prone to the development of insulin resistance. Higher levels of insulin were closely correlated with the postnatal height CUG in young SGA children and with the weight CUG in old children.

Keywords

Small for gestational age Catch-up growth Insulin resistance beta-Cell function 

Abbreviations

AGA

Appropriate for gestational age

SGA

Small for gestational age

CUG

Catch-up growth

NCUG

Non-catch-up growth

BMI

Body mass index

SD

Standard deviation

SDS

Standard deviation score(s)

IGF-1

Insulin-like growth factor-1

GH

Growth hormone

HOMA

Homeostasis assessment model

IR

Insulin resistance

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Hong-Zhu Deng
    • 1
  • Yan-Hong Li
    • 1
  • Zhe Su
    • 1
  • Hua-Mei Ma
    • 1
  • Yue-Fang Huang
    • 1
  • Hong-Shan Chen
    • 1
  • Min-Lian Du
    • 1
  1. 1.Department of Pediatrics, The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina

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