European Journal of Pediatrics

, Volume 169, Issue 12, pp 1557–1559 | Cite as

Kikuchi-Fujimoto disease: an amazing response to hydroxychloroquine

  • Po-Hung Chen
  • Yung-Feng Huang
  • Chia-Wan Tang
  • Shue-Ren Wann
  • Hong-Tai Chang
Short Report


Kikuchi-Fujimoto disease is a benign and self-limited disorder. The common clinical features are fever and cervical lymphadenitis. A 9-year-old girl with fever and cervical lymphadenitis was admitted because of persistent symptoms. A cervical lymph node biopsy showed the characteristic features of Kikuchi-Fujimoto disease. Herein, we will discuss the clinical features, diagnosis, and treatment of Kikuchi-Fujimoto disease and highlight the dramatic response when a patient was treated with hydroxychloroquine.


Kikuchi-Fujimoto disease Kikuchi’s disease Necrotizing lymphadenitis Hydroxychloroquine Fever 


Conflict of interest

The authors report no conflicts of interest or any financial relationships.


  1. 1.
    Chan JK, Wong KC, Ng CS (1989) A fatal case of multicentric Kikuchi’s histiocytic necrotizing lymphadenitis. Cancer 63:1856–1862CrossRefPubMedGoogle Scholar
  2. 2.
    Fujimoto Y, Kozima Y, Yamaguchi K (1972) Cervical subacute necrotizing lymphadenitis. A new clinicopathologic entity. Naika 30:920–927Google Scholar
  3. 3.
    Hutchinson CB, Wang E (2010) Kikuchi-Fujimoto disease. Arch Pathol Lab Med 134:289–293PubMedGoogle Scholar
  4. 4.
    Kikuchi M (1972) Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Acta Haematol Jpn 35:379–380Google Scholar
  5. 5.
    Koybasi S, Saydam L, Gungen Y (2003) Histiocytic necrotizing lymphadenitis of the neck. Am J Otolaryngol 24:344–347CrossRefPubMedGoogle Scholar
  6. 6.
    O’Neill D, O’Grady J, Variend S (1998) Child fatality associated with pathological features of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease). Pediatr Pathol Lab Med 18:79–88CrossRefPubMedGoogle Scholar
  7. 7.
    Onciu M, Medeiros LJ (2003) Kikuchi-Fujimoto lymphadenitis. Adv Anat Pathol 10:204–211CrossRefPubMedGoogle Scholar
  8. 8.
    Rezai K, Kuchipudi S, Chundi V et al (2004) Kikuchi-Fujimoto disease: hydroxychloroquine as a treatment. Clin Infect Dis 39:e124–e126CrossRefPubMedGoogle Scholar
  9. 9.
    Vila LM, Mayor AM, Silvestrini IE (2001) Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi’s disease. Lupus 10:126–128CrossRefPubMedGoogle Scholar
  10. 10.
    Wong CY, Law GT, Shum TT et al (2001) Pulmonary haemorrhage in a patient with Kikuchi disease. Monaldi Arch Chest Dis 56:118–120PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Po-Hung Chen
    • 1
  • Yung-Feng Huang
    • 2
  • Chia-Wan Tang
    • 2
  • Shue-Ren Wann
    • 1
  • Hong-Tai Chang
    • 1
  1. 1.Department of Emergency MedicineKaohsiung Veterans General HospitalKaohsiung CityTaiwan
  2. 2.Department of PediatricsKaohsiung Veterans General HospitalKaohsiung CityTaiwan

Personalised recommendations