European Journal of Pediatrics

, Volume 169, Issue 7, pp 833–838 | Cite as

The epidemiology of childhood poisonings in Cyprus

  • Maria KoliouEmail author
  • Chrystalla Ioannou
  • Kyriaki Andreou
  • Alexandra Petridou
  • Elpidoforos Soterakis Soteriades
Original Paper


Information on childhood poisonings in Cyprus is limited. Our objective was to examine the epidemiology of poisonings among children in Cyprus. All children up to 15 years of age admitted for poisoning to the Archbishop Makarios Hospital in Nicosia, Cyprus between 2005 and 2008 were included in our study. All hospital poisoning records were reviewed. A total of 257 children were admitted for poisoning. The mean age of children was 3.1 years, of which 83.7% were below the age of 5 years old, while 53% were boys. The poisoning hospitalizations accounted for about 3% of all admissions to the pediatric department during the study period (4 years). The annual cumulative incidence of childhood poisoning hospitalizations was 116 per 100,000 children. Medications accounted for 46.1% of all poisonings, the most frequent cause being paracetamol (9.8%), cardiovascular medications (5.3%), antitussive medications (4.5%), and other painkillers (4.1%). Another 37.6% of hospitalizations involved household products such as household cleaning products (11.8%), petroleum products (11.0%), and rodenticides (5.7%). Among children who ingested petroleum distillates, 55.6% developed clinical symptomatology. The vast majority of cases were accidental (93.8%). Suicidal cases involved children 8–14 years old, mainly girls, and the most frequent poisoning ingested was paracetamol (46.7%). Poisoning hospitalizations represent an important cause of morbidity among children in Cyprus. Preventive strategies should include the education of caregivers on the handling of medications and household products as well as legislation requiring child-resistant packaging for all medications and household products including petroleum distillates.


Poisonings Children Epidemiology Cyprus 



We would like to acknowledge Dr. Olga Kalakouta, Coordinator of the National Committee of the Ministry of Health for the prevention of childhood injuries, for her help regarding the Health campaigns and other current efforts toward the introduction of legislation for the prevention of injuries in Cyprus.

Conflict of interest

The authors declare that they have no financial and/or other relationship that may lead to a conflict of interest.

Authors’ contributions

MK and ESS conceived of the idea for the project. MK, CI, and KA collected and processed the data. AP performed and MK and ESS supervised the statistical analyses. All authors reviewed and interpreted the statistical analyses. MK and ESS wrote the first draft of the manuscript, while all authors contributed to the final version of the manuscript. All authors read and approved of the final version of the manuscript.


  1. 1.
    Amitai Y, Mitchell A, Carrel JC et al (1987) Patterns of calling time and ipecac availability among poison center callers. Am J Dis Child 141:622–625PubMedGoogle Scholar
  2. 2.
    Bateman DN, Bain M, Gorman D et al (2003) Changes in paracetamol, antidepressants and opioid poisoning in Scotland during the 1990s. QJM 96(2):125–132CrossRefPubMedGoogle Scholar
  3. 3.
    Campbell D, Oates RK (1992) Childhood poisoning—a changing profile with scope for prevention. Med J Aust 156:238–240PubMedGoogle Scholar
  4. 4.
    Chien C, Marriott JL, Ashby K et al (2003) Unintentional ingestion of over the counter medications in children less than 5 years old. J Paediatr Child Health 39(4):264–269CrossRefPubMedGoogle Scholar
  5. 5.
    Consumer Product Safety Commission: Poison Prevention Packaging Act of 1970 Regulations (1995) (codified at 16 CFR 1700.1)Google Scholar
  6. 6.
    Deykin EY, Perlow R, McNamarra J (1985) Non-fatal suicidal and life-threatening behavior among 13- to 17-year old adolescents seeking emergency medical care. Am J Public Health 75(1):90–92CrossRefPubMedGoogle Scholar
  7. 7.
    El-Naggar AEL-R, Abdalla MS, El-Sebaey AS et al (2009) Clinical findings and cholinesterase levels in children of organophosphates and carbamates poisoning. Eur J Pediatr 168:951–956CrossRefGoogle Scholar
  8. 8.
    Ferguson JA, Sellar C, Goldacre MJ (1992) Some epidemiological observations on medicinal and non-medicinal poisoning in preschool children. J Epid Comm Heal 46:207–210CrossRefGoogle Scholar
  9. 9.
    Franklin RL, Rodgers GB (2008) Unintentional child poisonings treated in United States hospital emergency departments: national estimates of incident cases, population-based poisoning rates, and product involvement. Pediatrics 122(6):1244–1251CrossRefPubMedGoogle Scholar
  10. 10.
    Fraser J, Mok Q (2001) Severe lung injury following aspiration of scented lamp oil. Intensive Care Med 27(3):614CrossRefPubMedGoogle Scholar
  11. 11.
    Hawkins LC, Edwards JN, Dargan PI (2007) Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature. Drug Saf 30(6):465–479, ReviewCrossRefPubMedGoogle Scholar
  12. 12.
    Hawton K, Harriss L (2008) Deliberate self-harm by under-15-year-olds: characteristics, trends and outcome. J Child Psychol Psychiatry 49(4):441–448, Epub 2007 Dec 11CrossRefPubMedGoogle Scholar
  13. 13.
    Lamireau T, Llanas B, Kennedy A et al (2002) Epidemiology of poisoning in children: a 7-year survey in a paediatric emergency care unit. Eur J Emerg Med 9(1):9–14CrossRefPubMedGoogle Scholar
  14. 14.
    Mahdi AH, Ali Taha S, Al Rifai MR (1983) Epidemiology of accidental home poisoning in Riyadh (Saudi Arabia). J Epid Comm Heal 37:291–295CrossRefGoogle Scholar
  15. 15.
    Marchi AG, Gallone G, Raspino M et al (1994) The risk associated with poisonings in children. Vet Hum Toxicol 36:112–116PubMedGoogle Scholar
  16. 16.
    McGuigan MA (1999) Common culprits in childhood poisoning: epidemiology, treatment and parental advice for prevention. Paediatr Drugs 1(4):313–324CrossRefPubMedGoogle Scholar
  17. 17.
    Melis K, Verbeke S, Bochner A (1990) Chemical pneumonia in children. Ned Tijdschr Geneeskd 134(16):811–814PubMedGoogle Scholar
  18. 18.
    Poison Information Centre, Children’s Hospital, Aglaia Kyriakou. Annual Data for 1993, Athens, GreeceGoogle Scholar
  19. 19.
    Rajka T, Heyerdahl F, Hovda KE et al (2007) Acute child poisonings in Oslo: a 2-year prospective study. Acta Paediatr 96(9):1355–1359CrossRefPubMedGoogle Scholar
  20. 20.
    Rhodes AE, Bethell J, Spence J et al (2008) Age-sex differences in medicinal self-poisonings: a population-based study of deliberate intent and medical severity. Soc Psychiatry Psychiatric Epidemiol 43(8):642–652, Epub 2008 May 29CrossRefGoogle Scholar
  21. 21.
    Scavenius M (1991) Acute poisonings in childhood: 607 admissions during a 5-year period to a Danish pediatric department. Ugenskr-Laeger 153:183–186Google Scholar
  22. 22.
    Sobel R, Margolis J (1965) Repetitive poisoning in children. A psychosocial study. Pediatrics 35:641–645PubMedGoogle Scholar
  23. 23.
    Squires RH Jr, Shneider BL, Bucuvalas J et al (2006) Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr 148(5):652–658CrossRefPubMedGoogle Scholar
  24. 24.
    Walton WW (1982) An evaluation of the Poison Prevention Packaging Act. Pediatrics 69(3):363–370PubMedGoogle Scholar
  25. 25.
    Watson WA, Litovitz TL, Klein-Schwartz W et al (2004) 2003 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 22(5):335–404CrossRefPubMedGoogle Scholar
  26. 26.
    Wiseman HM, Guest K, Murray VSG et al (1987) Accidental poisoning in childhood: a multicentre study. 1. general epdeimology. Hum Toxicol 6:293–301CrossRefPubMedGoogle Scholar
  27. 27.
    Woolf AD (1993) Poisoning in children and adolescents. Pediatr Rev 14:411–422PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Maria Koliou
    • 1
    • 3
    Email author
  • Chrystalla Ioannou
    • 1
  • Kyriaki Andreou
    • 1
  • Alexandra Petridou
    • 2
  • Elpidoforos Soterakis Soteriades
    • 3
    • 4
  1. 1.Department of PediatricsArchbishop Makarios HospitalNicosiaCyprus
  2. 2.Open University of CyprusNicosiaCyprus
  3. 3.Department of Occupational and Environmental MedicineCyprus Institute of Biomedical Sciences (CIBS)NicosiaCyprus
  4. 4.Department of Environmental HealthHarvard School of Public Health, Environmental and Occupational Medicine and Epidemiology (EOME)BostonUSA

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