European Journal of Pediatrics

, 169:237 | Cite as

Streptococcus pneumoniae-associated haemolytic uremic syndrome following influenza A virus infection

  • Tzu-Hui Lei
  • Shao-Hsuan Hsia
  • Chang-Teng Wu
  • Jainn-Jim Lin
Short Report

Abstract

Influenza virus is a seasonal cause of community-acquired pneumonia, and Streptococcus pneumoniae is one of the most common pathogens causing secondary bacterial pneumonia. S. pneumoniae-induced haemolytic uremic syndrome is an uncommon condition mainly observed in young children. We present a patient who had invasive pneumococcal disease and haemolytic uremic syndrome. Simultaneous viral cultures grew influenza A. To the best of our knowledge, this is the first such reported case.

Keywords

Streptococcus pneumoniae infection Haemolytic uremic syndrome influenza A virus 

References

  1. 1.
    Brandt J, Wong C, Miham S, Roberts J et al (2002) Invasive pneumococcal disease and haemolytic uremic syndrome. Pediatrics 110:371–376CrossRefPubMedGoogle Scholar
  2. 2.
    Cochran JB, Panzarino VM, Maes LY et al (2004) Pneumococcus-induced T-antigen activation in haemolytic uremic syndrome and anemia. Pediatr Nephrol 19:317–321CrossRefPubMedGoogle Scholar
  3. 3.
    Copelovitch L, Kaplan BS (2008) Streptococcus pneumoniae-associated hemolytic uremic syndrome. Pediatr Nephrol 23:1951–1956CrossRefPubMedGoogle Scholar
  4. 4.
    Erickson LC, Smith WS, Biswas AK et al (1994) Streptococcus pneumoniae-induced haemolytic uremic syndrome: a case for early diagnosis. Pediatr Nephrol 8:211–213CrossRefPubMedGoogle Scholar
  5. 5.
    Gilbert RD, Argent AC (1998) Streptococcus pneumoniae-associated haemolytic uremic syndrome. Pediatr Infec Dis J 17:530–532CrossRefGoogle Scholar
  6. 6.
    Huang RT, Dietsch E, Rott R (1985) Further studies on the role of neuraminidase and the mechanism of low pH dependence in influenza virus-induced membrane fusion. J Gen Virol 66(Pt 2):295–301CrossRefPubMedGoogle Scholar
  7. 7.
    McCullers JA (2006) Insights between influenza virus and pneumococcus. Clin Microbiol Rev 19:571–582CrossRefPubMedGoogle Scholar
  8. 8.
    McCullers JA (2004) Effect of antiviral treatment on the outcome of secondary bacterial pneumonia after influenza. J Infect Dis 190:519–526CrossRefPubMedGoogle Scholar
  9. 9.
    Moghal NE, Brocklebank JT, Meadow SR (1998) A review of acute renal failure in children: incidence, etiology and outcome. Clin Nephrol 49:91–95PubMedGoogle Scholar
  10. 10.
    Mohan SS, Vinay N, Cunha BA (2005) Post-viral influenza Streptococcus pneumoniae pneumonia in an intravenous drug abuser. Heart Lung 34:222–226CrossRefPubMedGoogle Scholar
  11. 11.
    Scheiring J, Rosales A, Zimmerhackl LB (2009) Clinical practice: Today’s understanding of the haemolytic uraemic syndrome. Eur J Pediatr Aug 26. [Epub ahead of print]Google Scholar
  12. 12.
    Watanabe T (2001) Hemolytic uremic syndrome associated with influenza A virus infection. Nephron 89:359–360CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tzu-Hui Lei
    • 1
  • Shao-Hsuan Hsia
    • 1
  • Chang-Teng Wu
    • 1
  • Jainn-Jim Lin
    • 1
  1. 1.Division of Pediatric Emergency Medicine, Chang Gung Children’s Hospital, Chan Gung Memorial HospitalChang Gung University College of MedicineTaoyuanRepublic of China

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