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European Journal of Pediatrics

, Volume 168, Issue 7, pp 833–838 | Cite as

Contribution of the blood glucose level in perinatal asphyxia

  • Pallab BasuEmail author
  • Sabbasachi Som
  • Nabendu Choudhuri
  • Harendranath Das
Original Paper

Abstract

This is a comparative study between 60 asphyxiated newborns (cases) and 60 normal neonates (controls) in respect of their plasma glucose and uric acid levels and also their clinical and neurological status. The mean plasma glucose level was significantly lower (35.1 ± 11.4 mg/dl vs. 56.9 ± 5.5 mg/dl; P < 0.001) and the mean serum uric acid level was higher (8.0 ± 1.2 mg/dl vs. 4.5 ± 0.83 mg/dl; P < 0.001) in the asphyxiated group when compared to the controls. Within the perinatal asphyxia group, the plasma glucose level and Apgar scores showed a significant positive linear correlation (r = 0.740, P < 0.001), whereas a significant negative linear correlation was observed between the glucose level and different stages of hypoxic ischemic encephalopathy (HIE) (r = −0.875, P < 0.001). Although a strong positive linear correlation was found between uric acid and HIE stages (r = 0.734, P ≤ 0.001), the linear correlation between uric acid and Apgar scores (r = −0.885, P < 0.001) and uric acid and the plasma glucose level (r = −0.725, P < 0.001) were found to be significantly negative among the cases. Conclusion: The severity of encephalopathy and cellular damage varies with the severity of hypoglycemia.

Keywords

Perinatal asphyxia Plasma glucose Serum uric acid Hypoxic ischemic encephalopathy Apgar score 

Abbreviations

ADP

Adenosine diphosphate

AMP

Adenosine monophosphate

ATP

Adenosine triphosphate

CBF

Cerebral blood flow

CP

Cerebral palsy

EEG

Electro-encephalography

GOD-POD

Glucose oxidase–peroxidase

HIE

Hypoxic ischemic encephalopathy

ROS

Reactive oxygen species

SPSS

Statistical Package for the Social Sciences

Notes

Acknowledgments

Mr. B. B. Mukherjee, Statistician, Department of Community Medicine, Burdwan Medical College, helped in carrying out the statistical analysis, Dr. Mousumi Tripathi helped in compiling the data, and Mr. M. K. Basu helped in structuring and formatting the manuscript.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Pallab Basu
    • 1
    • 3
    Email author
  • Sabbasachi Som
    • 2
  • Nabendu Choudhuri
    • 2
  • Harendranath Das
    • 1
  1. 1.Department of BiochemistryBurdwan Medical College and HospitalBurdwanIndia
  2. 2.Department of PediatricsBurdwan Medical College and HospitalBurdwanIndia
  3. 3.KolkataIndia

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