European Journal of Pediatrics

, Volume 167, Issue 9, pp 1021–1023

Successful resolution of cardiac mycetomas by combined liposomal Amphotericin B with Fluconazole treatment in premature neonates

  • Ageliki A. Karatza
  • Gabriel Dimitriou
  • Markos Marangos
  • Myrto Christofidou
  • Vassiliki Pavlou
  • Ioannis Giannakopoulos
  • Antonios Darzentas
  • Stefanos P. Mantagos
Original Paper

Abstract

This manuscript reports on two very low birth weight premature infants with respiratory distress, receiving parenteral nutrition and broad-spectrum antibiotics for about 3 weeks, who developed Candida albicans sepsis associated with fungal mycoses and endocarditis, despite treatment with Amphotericin B and Caspofungin. On days 40 and 47, respectively, antifungal therapy was modified to liposomal Amphotericin B combined with Fluconazole 6 mg/kg/day for 4 weeks, resulting in complete resolution of the mycetomas. Our observations suggest that the combination of liposomal Amphotericin B with Fluconazole is able to result in complete resolution of cardiac mycetomas in preterm infants.

Keywords

Neonatal Candida endocarditis Combination antifungal therapy Liposomal Amphotericin B Caspofungin Fluconazole 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ageliki A. Karatza
    • 1
  • Gabriel Dimitriou
    • 1
  • Markos Marangos
    • 2
  • Myrto Christofidou
    • 3
  • Vassiliki Pavlou
    • 1
  • Ioannis Giannakopoulos
    • 1
  • Antonios Darzentas
    • 1
  • Stefanos P. Mantagos
    • 1
  1. 1.Department of Paediatrics, Neonatal Intensive Care UnitGeneral University Hospital of PatrasRio, PatrasGreece
  2. 2.Department of Internal Medicine, Infectious Diseases SectionUniversity of Patras Medical SchoolRio, PatrasGreece
  3. 3.Department of MicrobiologyUniversity of Patras Medical SchoolRio, PatrasGreece

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