European Journal of Pediatrics

, Volume 167, Issue 2, pp 189–196 | Cite as

Endothelial dysfunction in adult patients with a history of Kawasaki disease

  • Ayumi Niboshi
  • Kenji Hamaoka
  • Koichi Sakata
  • Nozomi Yamaguchi
Original Paper


To assess the existence of endothelial dysfunction and the possibility of the early onset of atherosclerosis in the chronic stage of Kawasaki disease (KD), we examined endothelial function in adult patients late after the onset of KD. We evaluated two age-matched groups: 35 adult KD patients (KD group) (mean age, 27.0 years; mean interval time, 24.1 years), and 36 healthy adults (control group). To assess vascular endothelial function, flow-mediated dilatation (%FMD) of the brachial artery and urinary nitrites and nitrates (NOx) were examined. We also measured adhesion molecules and several coagulation-fibrinolysis markers. In addition, we measured high-sensitive C-reactive protein (hs-CRP) as a chronic inflammatory marker, and brachial-ankle pulse wave velocity (baPWV) as a marker for arterial stiffness. %FMD was significantly reduced in the KD group when compared with that of the control group (KD group, 10.4 ± 2.6%; control group, 14.4 ± 3.2%, p<0.05), particularly in patients with coronary artery lesions. Thrombin-antithrombin III complex values were higher in the KD group, although no significant differences were observed in the other markers for endothelial function. Hs-CRP was significantly elevated only in the patients with coronary aneurysms. Furthermore, in the male KD patients, the baPWV values were significantly higher than those in the control subjects. This study revealed that the adult patients with a history of KD had systemic vascular endothelial dysfunction, and also suggested that a history of KD was possibly one of the risk factors for early onset of atherosclerosis.


Kawasaki disease Adult Vascular endothelial function High-sensitive C-reactive protein Atherosclerosis 



kawasaki disease


coronary artery lesions


Flow-mediated dilatation


Isosorbide dinitrite


Endothelium-independent dilatation


systemic blood pressure


diastolic blood pressure




Nitrites and nitrates


Soluble intercellular adhesion molecule-1


Soluble vascular adhesion molecule-1


Thrombin-antithrombin III complex


Tissue plasminogen activator-plasminogen activator inhibitor-1 complex


Von Willebrand factor


high-sensitive C-reactive protein


body mass index


total cholesterol


High-density lipoprotein cholesterol


Low-density lipoprotein cholesterol




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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Ayumi Niboshi
    • 1
    • 3
  • Kenji Hamaoka
    • 1
  • Koichi Sakata
    • 1
  • Nozomi Yamaguchi
    • 2
  1. 1.Department of Pediatric Cardiology and NephrologyKyoto Prefectural University of Medicine Graduate School of Medical ScienceKyotoJapan
  2. 2.Department of Environmental Systems ScienceFaculty of Engineering, Doshisha UniversityKyotoJapan
  3. 3.Kamigyo-ku, KyotoJapan

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