European Journal of Pediatrics

, Volume 166, Issue 8, pp 813–818 | Cite as

Factors associated with immunoprophylaxis failure against vertical transmission of hepatitis B virus

  • Yun-Mi Song
  • Joohon Sung
  • Soonha Yang
  • Yon Ho Choe
  • Yun Sil Chang
  • Won Soon Park
Original Paper


In spite of adequate immunoprophylaxis, perinatal transmission of hepatitis B virus (HBV) has not been completely eliminated. This study evaluated the factors associated with the failure of HBV immunoprophylaxis. The study participants were 144 children who were born to HBsAg-seropositive mothers of known HBeAg status and they had received HB immune globulin and HB vaccine within 24 hours after birth followed by two further administrations of HB vaccine as recommended. Seventeen of the children (11.8%) suffered immunoprophylaxis failure, defined by HBsAg-seropositivity. The rate of HBV immunoprophylaxis failure was 12%, 0%, 21%, 0%, and 27% among the children born to HBsAg-seropositive, HBeAg-seronegative, HBeAg-seropositive, undetectable HBV DNA, and detectable HBV DNA mothers, respectively. The failure of HBV immunoprophylaxis was significantly associated with maternal HBeAg-seropositivity and HBV DNA seropositivity. To identify those children at high risk of HBV immunoprophylaxis failure, maternal HBeAg and HBV DNA need to be assessed prior to childbirth.


Disease transmission, vertical Hepatitis B Hepatitis B e antigens Hepatitis B surface antigens 



hepatitis B virus



The Samsung Biomedical Research Institute supported this work (Grant # SBRI CA10151).


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Yun-Mi Song
    • 1
  • Joohon Sung
    • 2
  • Soonha Yang
    • 3
  • Yon Ho Choe
    • 4
  • Yun Sil Chang
    • 4
  • Won Soon Park
    • 4
  1. 1.Department of Family Medicine, Samsung Medical Center, and Center for Clinical Research, Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Department of Preventive MedicineKangwon National University College of MedicineKangwan-DoSouth Korea
  3. 3.Department of Obstetrics and GynecologySamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea
  4. 4.Department of PediatricsSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea

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