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European Journal of Pediatrics

, Volume 166, Issue 2, pp 169–171 | Cite as

Hypokalemic rhabdomyolysis in a child due to amphotericin B therapy

  • Paulo Sérgio Lucas da Silva
  • Simone Brasil de Oliveira Iglesias
  • Jaques Waisberg
Original Paper

Abstract

Hypokalemia can result in life-threatening complications if not treated appropriately. Although hypokalemia is a frequent adverse effect of amphotericin B therapy, there are no reports in the pediatric literature on hypokalemia-associated rhabdomyolysis induced by this drug. A ten-year-old boy with a history of one week amphotericin B treatment was admitted with weakness of the lower extremities, inability to walk and calf pain. Laboratory tests showed a serum potassium of 1.7 mEq/L and a serum creatinine phosphokinase of 3937 U/L plus myoglobulinuria. Following fluid expansion and intravenous potassium replacement, the patient progressed to achieve full regression of muscular weakness after one week. This report highlights hypokalemia as a rare cause of rhabdomyolysis. Patients on amphotericin B should be checked for this rare yet potentially life-threatening complication.

Keywords

Hypokalemia Rhabdomyolysis Myoglobinuria Amphotericin B Children 

Abbreviations

ARF

acute renal failure

FeCl

fractional excretion of chloride

FeK

fractional excretion of potassium

FeNa

fractional excretion of sodium

CK

creatinine phosphokinase

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Paulo Sérgio Lucas da Silva
    • 1
    • 2
  • Simone Brasil de Oliveira Iglesias
    • 1
  • Jaques Waisberg
    • 1
  1. 1.Pediatric Intensive Care Unit, Department of PediatricsHospital do Servidor Público MunicipalSão PauloBrazil
  2. 2.São PauloBrazil

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