European Journal of Pediatrics

, Volume 165, Issue 7, pp 484–488 | Cite as

Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the literature

  • H. Mizumoto
  • T. Maihara
  • E. Hiejima
  • M. Shiota
  • A. Hata
  • S. Seto
  • T. Atsumi
  • T. Koike
  • D. HataEmail author
Original Paper


We describe two previously healthy children who had multiple ecchymoses several days after acute infection. In both cases, the prothrombin time (PT) and the activated partial thromboplastin time (APTT) were prolonged. Further examinations revealed the presence of lupus anticoagulant (LA), phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT), and low serum complement. In both cases, we confirmed the presence of a serum immune complex. The patients’ symptoms improved spontaneously within 1 week, and all laboratory data normalized within several months. We also describe another asymptomatic case positive for LA and aPS/PT presumably associated with cytomegalovirus infection. The prevalence of transient antiphospholipid antibodies associated with viral infections in children must be much higher than we expected. We have to take it into consideration when we see abnormal coagulation results, but the occurrence of significant bleeding symptoms is rare.


Lupus anticoagulant Phosphatidylserine-dependent antiprothrombin antibodies Hypoprothrombinemia Bleeding complications 



Antiphospholipid antibodies


Systemic lupus erythematosus


Lupus anticoagulant


LA-hypoprothrombinemia syndrome


Antiphospholipid syndrome


β2-glycoprotein I


Phosphatidylserine-dependent antiprothrombin antibodies


Dilute Russell viper venom time


Prothrombin time


Activated partial thromboplastin time


Enzyme-linked immunosorbent assay


Anticardiolipin antibodies


β2-GPI-dependent aCL


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • H. Mizumoto
    • 1
  • T. Maihara
    • 2
  • E. Hiejima
    • 3
  • M. Shiota
    • 1
  • A. Hata
    • 1
  • S. Seto
    • 3
  • T. Atsumi
    • 4
  • T. Koike
    • 4
  • D. Hata
    • 1
    Email author
  1. 1.Department of PediatricsKitano Hospital, Tazuke Kofukai Medical Research InstituteOsakaJapan
  2. 2.Department of PediatricsHyogo Prefectural Tsukaguchi HospitalAmagasakiJapan
  3. 3.Department of PediatricsKishiwada City HospitalKishiwadaJapan
  4. 4.Department of Medicine IIHokkaido University School of MedicineSapporoJapan

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