Arthritis in Kawasaki disease after responding to intravenous immunoglobulin treatment
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Pathologically, Kawasaki disease (KD) is a systemic vasculitis which can show some complications as arthritis during the natural course. It is observed usually in the acute or subacute stage of 15%–45% of KD patients [3, 4, 5].
The 5 children, out of 217 patients with KD, who presented with arthritis after defervescence on intravenous immunoglobulin (IVIG) treatment were retrospectively reviewed. All patients met the diagnostic criteria of KD at the initial time of presentation and patients 1, 2, 4 and 5 were readmitted because of arthritis. Initially, all patients were treated with IVIG at a dose of 2 g/kg, and with acetylsalicylic acid (30–50 mg/kg). Two patients (numbers 3 and 4) failed to respond the first dose of IVIG and became afebrile after the second dose of IVIG (1 g/kg). The arthritis was observed at mean of 10.4±1.3 days (range 8 to 13 days) after the onset of fever, and at a mean of 5.8±1.8 days (range 3 to 10 days) after defervescence after the final dose of IVIG. For the...
KeywordsArthritis Ibuprofen Kawasaki Disease Acetylsalicylic Acid Systemic Vasculitis
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- 1.Burgos-Vargas R, Vazquez-Melldo J (1993) Reactive arthritis. In: Cassidy JT, Petty RE (eds) Textbook of pediatric rheumatology, 4th edn. Saunders, New York, pp 679–705Google Scholar
- 2.Furusho K, Kamiya T, Nakano H, Kiyosawa N, Shinomiya K, Hayashidera T, Tamura T, Hirose O, Manabe Y, Yokoyama T (1984) High dose intravenous gamma globulin therapy for Kawasaki syndrome. Lancet 1: 1055–1058Google Scholar
- 3.Hicks RV, Melish ME (1979) Kawasaki syndrome: rheumatic complaints and analysis of salicylate therapy. Arthritis Rheum 22: 621–622Google Scholar
- 4.Kawasaki T (1967) Acute, febrile mucocutaneous lymph node syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children: clinical observation of 50 cases. Jpn J Allergy 16: 178–222Google Scholar
- 5.Melish ME (1982) Kawasaki syndrome (the mucocutaneous lymph node syndrome). Ann Pediatr 255–268Google Scholar
- 6.Newburger JW, Takahashi M, Beiser AS, Burns JC, Bastian J, Chung KJ, Colan SD, Duffy CE, Fulton DR, Glode MP (1986) The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med 315: 341–347Google Scholar
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