Arthritis in Kawasaki disease after responding to intravenous immunoglobulin treatment
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Pathologically, Kawasaki disease (KD) is a systemic vasculitis which can show some complications as arthritis during the natural course. It is observed usually in the acute or subacute stage of 15%–45% of KD patients [3, 4, 5].
The 5 children, out of 217 patients with KD, who presented with arthritis after defervescence on intravenous immunoglobulin (IVIG) treatment were retrospectively reviewed. All patients met the diagnostic criteria of KD at the initial time of presentation and patients 1, 2, 4 and 5 were readmitted because of arthritis. Initially, all patients were treated with IVIG at a dose of 2 g/kg, and with acetylsalicylic acid (30–50 mg/kg). Two patients (numbers 3 and 4) failed to respond the first dose of IVIG and became afebrile after the second dose of IVIG (1 g/kg). The arthritis was observed at mean of 10.4±1.3 days (range 8 to 13 days) after the onset of fever, and at a mean of 5.8±1.8 days (range 3 to 10 days) after defervescence after the final dose of IVIG. For the...
KeywordsArthritis Ibuprofen Kawasaki Disease Acetylsalicylic Acid Systemic Vasculitis
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