ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil

  • Farah Thabet
  • Rim Sghiri
  • Brahim Tabarki
  • Ibtissem Ghedira
  • Moncef Yacoub
  • Ahmed Sahloul Essoussi
Original Paper
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Abstract

Benzylthiouracil has been recently observed to be associated with antineutrophil cytoplasmic antibody-positive vasculitis, resulting in crescentic glomerulonephritis. We report an 8-year-old girl treated with benzylthiouracil for Graves’s disease who developed an ANCA-positive vasculitis with pulmonary hemorrhage. She responded to corticosteroids and discontinuation of benzylthiouracil. This represents the first pediatric case of benzylthiouracil-induced diffuse alveolar hemorrhage.

Keywords

Antineutrophil cytoplasmic antibody Vasculitis Diffuse alveolar hemorrhage Benzylthiouracil 

Abbreviations

ANCA

Antineutrophil cytoplasmic antibody

DAH

Diffuse alveolar hemorrhage

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Farah Thabet
    • 1
    • 3
  • Rim Sghiri
    • 2
  • Brahim Tabarki
    • 1
  • Ibtissem Ghedira
    • 2
  • Moncef Yacoub
    • 1
  • Ahmed Sahloul Essoussi
    • 1
  1. 1.Department of PediatricsHospital Farhat HachedSousseTunisia
  2. 2.Department of ImmunologyHospital Farhat HachedSousseTunisia
  3. 3.Service de pediatrieHospital Farhat HachedSousseTunisia

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