Status epilepticus due to attempted suicide with isoniazid
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As the incidence of tuberculosis among immigrants to Western European countries is currently increasing, a rise in usage of isoniazid (INH) and, consequently, occurrence of acute and chronic INH intoxication should be expected . We report a case of a female adolescent with intentional INH overdosage resulting in status epilepticus and encephalitis-like signs and symptoms.
A previously healthy 10-year old girl was found presenting with noisy, irregular breathing during night sleep. She repeatedly vomited, was agitated and not fully responsive to commands. After 15 minutes she had prolonged generalised tonic-clonic seizures, which were finally successfully treated with repeated doses of intravenous midazolam. However, she remained in a state of reduced conscience, only responsive to painful stimuli. An empty blister packet of 25 tablets of 200-mg of INH was found beside her bed.
On arrival at the emergency unit she still was verbally unresponsive, agitated, and presented with...
KeywordsIsoniazid Intoxication Status epilepticus