European Journal of Pediatrics

, Volume 164, Issue 3, pp 141–145 | Cite as

Plasma aldosterone levels in the 1st week of life in infants of less than 30 weeks gestation

Original Paper

Abstract

Plasma aldosterone levels were measured in 50 infants of less than 30 weeks gestation at 24 h (D1) and 7 days (D7). The relationship between the plasma aldosterone level and a number of clinical and biochemical variables was explored. Plasma aldosterone levels ranged from 1000 to 30000 pmol/l and were inversely correlated with the severity of illness (D1 or D7), serum sodium (D7) and 24 h sodium intake (D1). No correlation with the serum potassium level was noted. Conclusion:Plasma aldosterone levels in this extremely premature cohort were significantly greater than those reported in more mature infants. Important determinants were severity of illness and sodium homeostasis.

Keywords

Plasma aldosterone Preterm 

Abbreviations

CRIB

clinical risk index for babies

MAP

mean arterial blood pressure

RAAS

renin-angiotensin-aldosterone system

Notes

Acknowledgements

The author thanks the Waikato Medical Research Foundation for funding this study and Dr P. J. Weston for the statistical analysis.

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Newborn Intensive Care UnitWaikato HospitalHamilton New Zealand

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