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European Journal of Pediatrics

, Volume 164, Issue 1, pp 9–12 | Cite as

High prevalence of coeliac disease in siblings of children with type 1 diabetes

  • Zdenek Sumnik
  • Stanislava Kolouskova
  • Hana Malcova
  • Jan Vavrinec
  • Jitrenka Venhacova
  • Jan Lebl
  • Ondrej Cinek
Original Paper

Abstract

Coeliac disease has been shown to occur more frequently among first-degree relatives of diabetic patients than in the general population. Our objective was to assess the prevalence of endomysium antibodies (EMA) in non-diabetic siblings of Czech diabetic children and to evaluate the effects of HLA-DQ polymorphisms in determining the genetic susceptibility to coeliac disease (CD) in these subjects. We investigated 240 siblings of diabetic children from 213 families (125 males and 115 females, aged 12.6±4.9 years, mean ± SD). All subjects were tested for the total IgA level to exclude IgA deficiency, and for endomysium IgA to disclose CD. In five IgA-deficient subjects, anti-gliadin IgG was used instead. Small bowel biopsy was offered to subjects with confirmed positive EMA. The HLA-DQA1, -DQB1 genotypes were determined using PCR-SSP. Positive EMA were found in 9/240 (3.8%) subjects (three males, six females). The biopsy confirmed CD in six children, two had a normal mucosal finding and one refused the biopsy. The HLA-DQ2 polymorphism was more frequent among siblings with EMA (seven of nine) than in siblings without EMA (33%), corrected P =0.031. Conclusion:The 3.8% frequency of coeliac disease found in siblings of diabetic children is close to the 4.3% found previously in Czech children with type 1 diabetes mellitus and is substantially higher than the rate in the healthy children population.

Keywords

Coeliac disease HLA Prevalence Relatives Type 1 diabetes 

Abbreviations

CD

coeliac disease

EMA

endomysial antibodies

GFD

gluten-free diet

T1DM

type 1 diabetes

Notes

Acknowledgements

This work was supported by the Ministry of Education of the Czech Republic (grant 111300003).

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Zdenek Sumnik
    • 1
  • Stanislava Kolouskova
    • 1
  • Hana Malcova
    • 1
  • Jan Vavrinec
    • 1
  • Jitrenka Venhacova
    • 2
  • Jan Lebl
    • 3
  • Ondrej Cinek
    • 1
  1. 1.Department of Paediatrics2nd Faculty of MedicinePrague 5 Czech Republic
  2. 2.Department of PaediatricsFaculty of Medicine, Palacky UniversityOlomouc Czech Republic
  3. 3.Department of Paediatrics3rd Faculty of Medicine, Charles UniversityPrague Czech Republic

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