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European Journal of Pediatrics

, Volume 161, Issue 2, pp 94–98 | Cite as

High density lipoprotein-cholesterol changes in children with high cholesterol levels at birth

  • Sara Bastida
  • Francisco J. Sánchez-Muniz
  • Rafael Cuena
  • Sagrario Perea
  • Angel Aragonés
Original Paper

Abstract.

The predictive value of serum lipoprotein concentrations at birth for the same parameters later in life is under debate. A group of 20 children displaying high total cholesterol (TC) levels at birth (group 2) were compared at age 4 years with 18 control children who had presented a normal lipoprotein profile at birth (group 1). There was a significant correlation between TC, low density lipoprotein-cholesterol, high density lipoprotein (HDL)-cholesterol, and apolipoprotein (Apo) A-I levels at age 4 years and at birth. The increases in TC and HDL-cholesterol levels from birth to age 4 years were significantly lower (P<0.05, P<0.01, respectively) in group 2 than in the control group and inversely correlated with the concentrations of these parameters at birth. The increases in HDL-cholesterol and Apo A-I levels were higher in males while those of triacylglycerol and Apo B were higher in females (P<0.05). However, the increases in TC and HDL-cholesterol were higher in controls (P<0.05). Diets of children of both groups were similar regarding the energy contribution of saturated, monounsaturated and polyunsaturated fatty acids, although children from group 2 ate less fish and ω-3 fatty acids (P<0.05). Conclusion: the present data suggest for the first time that when high density lipoprotein-cholesterol levels are high at birth, those levels increase less during the first four years of life. Moreover, low density lipoprotein-cholesterol increased about five times as much as high density lipoprotein-cholesterol did in controls and about 15 times as much as in the children with high cholesterol at birth.

Apolipoproteins A-I and B Children Cholesterol Diet Triacylglycerols 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Sara Bastida
    • 1
  • Francisco J. Sánchez-Muniz
    • 1
  • Rafael Cuena
    • 2
  • Sagrario Perea
    • 3
  • Angel Aragonés
    • 4
  1. 1.Departamento de Nutrición, Facultad de Farmacia, Universidad Complutense, 28040 MadridSpain
  2. 2.Servicio de Farmacología Clínica, Hospital Virgen de la Salud, 45006 ToledoSpain
  3. 3.Servicio de Farmacia, Hospital Virgen de la Salud, 45006 ToledoSpain
  4. 4.Servicio de Pediatría, Hospital Virgen de la Salud, 45006 ToledoSpain

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