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Medical Microbiology and Immunology

, Volume 190, Issue 1–2, pp 47–50 | Cite as

Heat shock protein 100 and the amastigote stage-specific A2 proteins of Leishmania donovani

  • Joachim Clos
  • Linda Klaholz
  • Manfred Kroemer
  • Sylvia Krobitsch
  • Susan Lindquist
Leishmania and the Leishmaniases

Abstract.

HSP100 protein in Leishmania spp. plays an important role for the survival and integrity of intracellular amastigotes. The A2 proteins of L. donovani are functionally linked to HSP100. There is evidence for an interdependence between these two proteins, which are both expressed predominantly in the amastigote stage of Leishmania donovani. Mutant strains lacking either of these proteins display very similar phenotypes, i.e. loss of virulence both in vivo and in vitro. Also, both proteins colocalise specifically to small foci within the cytoplasm of amastigotes.

Keywords

Trypanosoma Brucei Heat Shock Gene Leishmania Donovani Intracellular Amastigotes Immune Electron Microscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Joachim Clos
    • 1
  • Linda Klaholz
    • 1
  • Manfred Kroemer
    • 1
  • Sylvia Krobitsch
    • 1
  • Susan Lindquist
    • 2
  1. 1.Bernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyGermany
  2. 2.Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USAUSA

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