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Medical Microbiology and Immunology

, Volume 205, Issue 4, pp 371–379 | Cite as

Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS)

  • Manuela Bonizzoli
  • Rosaria Arvia
  • Simona di Valvasone
  • Francesco Liotta
  • Krystyna Zakrzewska
  • Alberta AzziEmail author
  • Adriano Peris
Original Investigation

Abstract

Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). ARDS and pneumonia are closely related to critically ill patients; however, the etiologic agent is not always identified. The presence of human herpes simplex virus 1, human cytomegalovirus and Epstein–Barr virus in respiratory samples of critically ill patients is increasingly reported even without canonical immunosuppression. The main aim of this study was to better understand the significance of herpesviruses finding in lower respiratory tract of ARDS patients hospitalized in ICU. The presence of this group of herpesviruses, in addition to the research of influenza viruses and other common respiratory viruses, was investigated in respiratory samples from 54 patients hospitalized in ICU, without a known microbiological causative agent. Moreover, the immunophenotype of each patient was analyzed. Herpesviruses DNA presence in the lower respiratory tract seemed not attributable to an impaired immunophenotype, whereas a significant correlation was observed between herpesviruses positivity and influenza virus infection. A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. In conclusion, these results indicate that herpesviruses lower respiratory tract infection, which occurs more frequently following influenza virus infection, can be a negative prognostic marker. An independent risk factor for ICU patients with ARDS is an impaired immunophenotype.

Keywords

Herpesvirus 1 Cytomegalovirus Epstein–Barr virus Influenza viruses Intensive therapy Acute respiratory distress syndrome 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Manuela Bonizzoli
    • 1
  • Rosaria Arvia
    • 2
  • Simona di Valvasone
    • 1
  • Francesco Liotta
    • 2
  • Krystyna Zakrzewska
    • 2
  • Alberta Azzi
    • 2
    Email author
  • Adriano Peris
    • 1
  1. 1.Intensive Care Unit and Regional ECMO Referral CenterAzienda Ospedaliero-Universitaria CareggiFlorenceItaly
  2. 2.Department of Experimental and Clinical MedicineUniversity of FlorenceFlorenceItaly

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