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Medical Microbiology and Immunology

, Volume 204, Issue 5, pp 557–565 | Cite as

The innate immune roles of host factors TRIM5α and Cyclophilin A on HIV-1 replication

Review

Abstract

During the long-term evolutionary history, the interaction between virus and host has driven the first-line barrier, innate immunity, to invading pathogens. Innate immune factor TRIM5α and host peptidyl-prolyl cistrans isomerase Cyclophilin A are two key players in the interaction between HIV-1 and host. Interestingly, Cyclophilin A is retrotransposed into the critical host gene, TRIM5, locus via LINE-1 element in some primate species including New World monkeys and Old World monkeys. This review aims to comprehensively discuss the sensing and immune activation procedures of TRIM5α innate signaling pathway through Cyclophilin A. It will then present the production of TRIMCyp chimeric gene and the different fusion patterns in primates. Finally, it will summarize the distinct restriction activity of TRIMCyp from different primates and explain the current understanding on the innate immune mechanisms involved in the early phase of the viral life cycle during HIV-1 replication.

Keywords

TRIM5α Cyclophilin A HIV-1 Innate immune 

Notes

Acknowledgments

This work was supported in part by Grants from the Science and Technology Planning Project of Guangdong Province, China (2012B031800267), the Natural Science Foundation of Guangdong Province, China (S2013010011860), the National Natural Science Foundation of China (31200130 and 81371812) to Dr. Kuang, and Grants from the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81172876, 30671960 and U0832601) and the Knowledge Innovation Program of Chinese Academy of Sciences (KJZD-EW-L10-02) to Dr. Zheng.

Conflict of interest

All contributing authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Yi-Qun Kuang
    • 1
    • 2
  • Hong-Liang Liu
    • 3
  • Yong-Tang Zheng
    • 4
  1. 1.Center for Translational Medicine, Huaihe Clinical InstituteHenan UniversityKaifengPeople’s Republic of China
  2. 2.Guangdong Institute of Public HealthGuangdong Center for Disease Control and PreventionGuangzhouPeople’s Republic of China
  3. 3.Pharmaceutical CollegeHenan UniversityKaifengPeople’s Republic of China
  4. 4.Key Laboratory of Animal Models and Human Diseases Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyChinese Academy of SciencesKunmingPeople’s Republic of China

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