Medical Microbiology and Immunology

, Volume 203, Issue 1, pp 57–63 | Cite as

HIV-1 progression links with viral genetic variability and subtype, and patient’s HLA type: analysis of a Nairobi-Kenyan cohort

  • Syed Hani Abidi
  • Aniqa Shahid
  • Laila S. Lakhani
  • Reena Shah
  • Nancy Okinda
  • Peter Ojwang
  • Farhat Abbas
  • Sarah Rowland-Jones
  • Syed Ali
Original Investigation

Abstract

In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient’s HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients’ viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection.

Keywords

HIV Kenya Progression markers Subtype HLA Genetic variability 

Notes

Acknowledgments

For this study, Syed Hani Abidi’s training was funded by HIV Research Trust (Scholarship No. HIVRT 10-059).

Conflict of interest

Authors declare no conflict of interest.

Supplementary material

430_2013_314_MOESM1_ESM.doc (56 kb)
Supplementary material 1 (DOC 56 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Syed Hani Abidi
    • 1
  • Aniqa Shahid
    • 1
  • Laila S. Lakhani
    • 2
  • Reena Shah
    • 3
  • Nancy Okinda
    • 4
  • Peter Ojwang
    • 4
  • Farhat Abbas
    • 5
  • Sarah Rowland-Jones
    • 6
  • Syed Ali
    • 1
  1. 1.Department of Biological and Biomedical SciencesAga Khan UniversityKarachiPakistan
  2. 2.Medical CollegeAga Khan UniversityKarachiPakistan
  3. 3.Department of MedicineAga Khan University HospitalNairobiKenya
  4. 4.Department of PathologyAga Khan University HospitalNairobiKenya
  5. 5.Department of SurgeryAga Khan UniversityKarachiPakistan
  6. 6.MRC Human Immunology UnitOxford UniversityOxfordUK

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