Medical Microbiology and Immunology

, Volume 201, Issue 3, pp 297–302

Serological response to influenza A H1N1 vaccine (Pandemrix®) and seasonal influenza vaccine 2009/2010 in renal transplant recipients and in hemodialysis patients

  • Undine Ott
  • Andreas Sauerbrei
  • Jeannette Lange
  • Anna Schäfler
  • Mario Walther
  • Gunter Wolf
  • Peter Wutzler
  • Roland Zell
  • Andi Krumbholz
Original Investigation

Abstract

In the present study, antibody response to seasonal influenza vaccination and to the adjuvanted one-shot influenza A H1N1 vaccine (Pandemrix®) was investigated in 57 hemodialysis (HD) patients and 48 renal transplant (RT) recipients. Specific antibodies were measured by hemagglutination inhibition (HI) test using a pandemic H1N1 strain and a seasonal H3N2 virus. HI titers of ≥1:40 were considered as protective. Hemodialysis patients showed seroprotection against pandemic H1N1 in 35.1%, against seasonal influenza in 36.8% and against both in 14.0%. In comparison, renal transplant recipients developed protective antibody titers against the pandemic H1N1 virus in 47.9%, against the seasonal H3N2 strain in 31.3% and against both in 18.8%. HD patients and renal transplant recipients younger than 60 years developed protective antibody response to the pandemic influenza H1N1 vaccine in 50.0% of the HD patients and 55.2% of the RT recipients and against seasonal influenza in 45.0/20.7% (HD/RT) of the cases. Patients aged ≥60 years showed seroprotection against pandemic influenza in 27.0/36.8% (HD/RT) and against seasonal influenza in 32.4/47.4% (HD/RT). Side effects were reported in only four patients. In hemodialysis patients and renal transplant recipients, vaccination against pandemic H1N1 and seasonal influenza is well tolerated. However, more than a half of these patients did not develop seroprotective antibody levels. Thus, new vaccines and altered vaccination regimes are likely necessary to achieve relevant antibody levels in these patient groups.

Keywords

Hemodialysis Kidney transplantation Influenza Pandemic H1N1 Vaccination Seroprotection 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Undine Ott
    • 1
  • Andreas Sauerbrei
    • 2
  • Jeannette Lange
    • 2
  • Anna Schäfler
    • 2
  • Mario Walther
    • 3
  • Gunter Wolf
    • 4
  • Peter Wutzler
    • 2
  • Roland Zell
    • 2
  • Andi Krumbholz
    • 2
    • 5
  1. 1.KfH NierenzentrumJenaGermany
  2. 2.Department of Virology and Antiviral Therapy, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  3. 3.Department of Medical Statistics, Computer Sciences and Documentation, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  4. 4.Department of Internal Medicine III, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  5. 5.Department of Medical Microbiology, Jena University HospitalFriedrich Schiller University JenaJenaGermany

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