Medical Microbiology and Immunology

, Volume 200, Issue 2, pp 69–75

Current knowledge on PB1-F2 of influenza A viruses

  • Andi Krumbholz
  • Anja Philipps
  • Hartmut Oehring
  • Katja Schwarzer
  • Annett Eitner
  • Peter Wutzler
  • Roland Zell
Review

DOI: 10.1007/s00430-010-0176-8

Cite this article as:
Krumbholz, A., Philipps, A., Oehring, H. et al. Med Microbiol Immunol (2011) 200: 69. doi:10.1007/s00430-010-0176-8
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Abstract

Almost 10 years ago, an eleventh protein of influenza A viruses was discovered in a search for CD8+ T-cell epitopes. This protein was named PB1-F2 since it is encoded in the +1 reading frame of the PB1 gene segment. Various studies have shown that PB1-F2 has a pleiotropic effect: (1) The protein can induce apoptosis in a cell type-dependent manner, (2) PB1-F2 is able to promote inflammation, and (3) finally it up-regulates viral polymerase activity by its interaction with the PB1 subunit. These properties could contribute to an enhanced pathogenicity. However, the underlying mechanism is not fully understood yet. New data suggest that some effects of PB1-F2 are strain-specific and host-specific.

Keywords

Influenza A virus Alternative open reading frame Protein Pathogenesis 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Andi Krumbholz
    • 1
    • 3
  • Anja Philipps
    • 1
  • Hartmut Oehring
    • 2
  • Katja Schwarzer
    • 3
  • Annett Eitner
    • 2
  • Peter Wutzler
    • 1
  • Roland Zell
    • 1
  1. 1.Department of Virology and Antiviral Therapy, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  2. 2.Department of Anatomy II, Jena University HospitalFriedrich Schiller University JenaJenaGermany
  3. 3.Department of Medical Microbiology, Jena University HospitalFriedrich Schiller University JenaJenaGermany

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