The clinical value of neutrophil extracellular traps

  • Tim Lögters
  • Stefan Margraf
  • Jens Altrichter
  • Jindrich Cinatl
  • Steffen Mitzner
  • Joachim Windolf
  • Martin Scholz
Review

Abstract

Neutrophil extracellular traps (NETs) have recently been discovered as a central part of antimicrobial innate immunity. In the meanwhile, evidence accumulated that NETs are also generated upon non-infectious stimuli in various clinical settings. In acute or chronic inflammatory disorders aberrantly enhanced NET formation and/or decreased NET degradation seems to correlate with disease outcome. This review summarizes current knowledge about the relation of NETs in a broad spectrum of clinical settings. Specifically, we focus on the importance of NETs as a predictive marker in severely ill patients and further, we speculate about the potential pathophysiology of NETs.

Keywords

Neutrophils Innate immunity Pathophysiology Neutrophil extracellular traps 

Notes

Acknowledgments

We thank Julia Quathamer for the fluorescence staining and photographs of NETs and Coelestina Scholz for the graphics depicted in Fig. 2. We appreciated the critical review of the manuscript by Dr Vidya Prasad and the support of Rose Garden.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tim Lögters
    • 1
  • Stefan Margraf
    • 1
  • Jens Altrichter
    • 1
  • Jindrich Cinatl
    • 2
  • Steffen Mitzner
    • 3
  • Joachim Windolf
    • 1
  • Martin Scholz
    • 1
  1. 1.Department of Trauma and Hand SurgeryHeinrich-Heine UniversityDüsseldorfGermany
  2. 2.Institute for Medical VirologyJohann Wolfgang Goethe UniversityFrankfurt am MainGermany
  3. 3.Division of Nephrology, Department of Internal MedicineUniversity of RostockRostockGermany

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