Medical Microbiology and Immunology

, Volume 195, Issue 2, pp 101–105 | Cite as

Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate

  • Astrid MeerbachEmail author
  • Andreas Sauerbrei
  • Werner Meerbach
  • Hans-Jörg Bittrich
  • Peter Wutzler
Original Investigation


In neonates, herpes simplex virus (HSV) infections can lead to severe diseases associated with high mortality. We report a 6-day-old girl who developed clinical signs of fulminant hepatic failure accompanied by infectious-toxic shock and disseminated coagulopathy secondary to HSV type 1 (HSV-1) infection. The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies.


HSV-1 infection Neonatal herpes Polymerase chain reaction Sepsis 


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Astrid Meerbach
    • 1
    Email author
  • Andreas Sauerbrei
    • 1
  • Werner Meerbach
    • 2
  • Hans-Jörg Bittrich
    • 3
  • Peter Wutzler
    • 1
  1. 1.Institute of Virology and Antiviral TherapyFriedrich-Schiller University of JenaJenaGermany
  2. 2.Institute of PathologyHelios Clinic ErfurtErfurtGermany
  3. 3.Department of PediatricsHelios Clinic ErfurtErfurtGermany

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