Medical Microbiology and Immunology

, Volume 193, Issue 4, pp 173–180 | Cite as

Miltefosine (Impavido): the first oral treatment against leishmaniasis

  • H. Sindermann
  • S. L. Croft
  • K. R. Engel
  • W. Bommer
  • H. J. Eibl
  • C. Unger
  • J. EngelEmail author
Original Investigation


Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently recommended antileishmanial drugs that require parenteral administration. Miltefosine produces high cure rates also in patients resistant to the standard antimonial therapy.


Visceral leishmaniasis Miltefosine Oral activity Antimonial resistance 


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • H. Sindermann
    • 1
  • S. L. Croft
    • 2
  • K. R. Engel
    • 3
  • W. Bommer
    • 3
  • H. J. Eibl
    • 4
  • C. Unger
    • 5
  • J. Engel
    • 1
    Email author
  1. 1.Zentaris AGFrankfurt am MainGermany
  2. 2.London School of Hygiene and Tropical MedicineLondonUK
  3. 3.Georg-August-University of GöttingenInstitute of HygieneGöttingenGermany
  4. 4.Max-Planck-Institut für Biophysikalische ChemieGöttingenGermany
  5. 5.Klinik für TumorbiologieFreiburgGermany

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